Possible Interactions with: S-Adenosylmethionine (SAMe)

Interactions

If you are being treated with any of the following medications, you should not use SAMe without first talking to your health care provider.

Taking SAMe at the same time as these drugs may increase the risk of serotonin syndrome (a potentially dangerous condition caused by having too much serotonin in your body):

  • Dextromethorphan (Robitussin DM, other cough syrups)
  • Meperidine (Demerol)
  • Pentazocine (Talwin)
  • Tramadol (Ultram)

Antidepressant medications -- SAMe may interact with antidepressant medications, increasing the potential for side effects including headache, irregular or accelerated heart rate, anxiety, and restlessness. Talk to your doctor before using SAMe if you are taking any medications for depression or anxiety.

Levodopa (L-dopa) -- SAMe may reduce the effectiveness of this medication for Parkinson’s disease.

Medications for diabetes -- SAMe may reduce levels of blood sugar and may strengthen the effect of diabetes medications, which increases the risk of hypoglycemia (low blood sugar).

Drug Interactions

Antidepressant Medications

Alternative Names

ademetionine; S-Adenosylmethionine (SAMe); SAMe

Review Date: 2007-09-30 Reviewed By: Steven D. Ehrlich, NMD, private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network. Keywords: ,
Adam Data Copyright The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only--they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

For information 410.787.4000

© 2013 UM Baltimore Washington Medical Center.  All rights reserved.

301 Hospital Drive, Glen Burnie, MD 21061 | 410-787-4000 | TTY 410-787-4498