Calcium Carbonate and Simethicone


(KAL see um KAR bun ate & sye METH i kone)

U.S. Brand Names

Titralac® Plus [OTC]


Simethicone and Calcium Carbonate

Generic Available



Relief of acid indigestion, heartburn

Pregnancy Risk Factor


Drug Interactions

See individual agents.


See individual agents.


Oral (OTC labeling): Adults: Two tablets every 2-3 hours as needed (maximum: 19 tablets/24 hours)


Tablets may be chewed, swallowed whole, or allowed to melt in the mouth.

Patient Education

Follow instructions for dosing. Take with a full glass of water or juice, 1-3 hours after other medications and 1-2 hours before any iron supplements. Avoid other antacids, caffeine, or other calcium supplements unless approved by prescriber. You may experience constipation (increased exercise, fluids, fruit, or fiber may help). Report severe, unresolved GI disturbances and unusual emotional lability (mood swings). Inform prescriber if you are or intend to become pregnant. Consult prescriber if breast-feeding.

Pregnancy/breast-feeding precautions:

Additional Information

40% of calcium carbonate is elemental calcium

Dental Health: Effects on Dental Treatment

Do not give tetracyclines concomitantly.

Dental Health: Vasoconstrictor/Local Anesthetic Precautions

No information available to require special precautions

Mental Health: Effects on Mental Status

None reported

Mental Health: Effects on Psychiatric Treatment

None reported

Dosage Forms

Tablet, chewable: Calcium carbonate 420 mg and simethicone 21 mg [equivalent to elemental calcium 168 mg; sugar free; spearmint flavor]

Review Date: 1969-12-31 Reviewed By: Keywords: ,
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