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Benadryl® Allergy and Sinus Fastmelt™ [OTC]; Benadryl® Allergy/Sinus [OTC]; Benadryl® Children's Allergy and Cold Fastmelt™ [OTC]; Benadryl® Children's Allergy and Sinus [OTC]
Pseudoephedrine and Diphenhydramine
Relief of symptoms of upper respiratory mucosal congestion in seasonal and perennial nasal allergies, acute rhinitis, rhinosinusitis, and eustachian tube blockage
See individual agents.
Diphenhydramine: CYP2D6 (moderate)Inhibits
Also see individual agents.
Based on component:pseudoephedrine
Adults: Oral: 60 mg every 4-6 hours, maximum: 240 mg/day
Key adverse event(s) related to dental treatment: Pseudoephedrine: Xerostomia (normal salivary flow resumes upon discontinuation). Chronic use of antihistamines will inhibit salivary flow, particularly in elderly patients; this may contribute to periodontal disease and oral discomfort.
Use with caution since pseudoephedrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response
Diphenhydramine may cause paradoxical excitation in pediatric patients, and can result in hallucinations, coma, and death in overdose. May cause sedation, sleepiness, dizziness, disturbed coordination, headache, fatigue, nervousness, paradoxical excitement, insomnia, euphoria, or confusion. Pseudoephedrine may cause dizziness, drowsiness, nervousness, and insomnia; may rarely cause hallucinations.
Rare reports of agranulocytosis and thrombocytopenia; use caution with clozapine, carbamazepine, and valproic acid; may increase gastric degradation of levodopa and decrease the amount of levodopa absorbed by delaying gastric emptying. Therapeutic effects of cholinergic agents (tacrine, donepezil, rivastigmine, galantamine) and neuroleptics may be antagonized. Central and/or peripheral anticholinergic syndrome can occur when administered with amantadine, rimantadine, narcotic analgesics, phenothiazines, and other antipsychotics (especially with high anticholinergic activity), tricyclic antidepressants and antihistamines. Pseudoephedrine is contraindicated with MAO inhibitors.
Liquid (Benadryl® Children's Allergy and Sinus): Diphenhydramine hydrochloride 12.5 mg and pseudoephedrine hydrochloride 30 mg per 5 mL [contains sodium benzoate; alcohol free, sugar free; grape flavor]
Tablet: Benadryl® Allergy/Sinus: Diphenhydramine hydrochloride 25 mg and pseudoephedrine hydrochloride 60 mg
Tablet, quick-dissolving: Benadryl® Children's Allergy and Cold Fastmelt™, Benadryl® Allergy and Sinus Fastmelt™: Diphenhydramine citrate 19 mg [equivalent to diphenhydramine hydrochloride 12.5 mg] and pseudoephedrine 30 mg [contains phenylalanine 4.6 mg/tablet; cherry flavor]