Silver Sulfadiazine (SIL-ver sul-fa-DYE-a-zeen)
Prevents and treats skin infections in patients with severe burns.
There may be other brand names for this medicine.
SSD, Silvadene, Thermazene
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to silver sulfadiazine. Do not use this medicine on pregnant women approaching or near giving birth, premature babies, or newborn babies 2 months of age and younger.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- This medicine is for use on the skin only. Do not get it in your eyes, nose, or mouth. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.
- Wash your hands with soap and water before and after using this medicine.
- Before using the cream, clean off any dead skin or scabbing from the burn wound.
- Wear sterile gloves to apply this medicine.
- Spread a thin layer of the cream over the wound. You may then cover the wound with a bandage if needed.
- Keep the wound area clean and covered with the medicine at all times.
- If the cream washes off during a bath or other activity, clean the wound again and put on more cream.
- To help clear up your skin or burn infection completely, keep using this medicine for the full time of treatment. You should keep using this medicine until the burned area has healed or is ready for skin grafting.
If a dose is missed:
- If you miss a dose or forget to use your medicine, apply it as soon as you can. If it is almost time for your next dose, wait until then to apply the medicine and skip the missed dose. Do not apply extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using cimetidine (Tagamet®).
- Do not use cosmetics or other skin care products on the treated skin areas.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or an enzyme problem called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- This medicine is a sulfa drug (sulfonamide). Rarely, this topical cream might cause some of the side effects seen with oral sulfa drugs. This includes allergic reactions. Check with your doctor right away if you have a blistering, peeling, red skin rash or other severe symptoms (such as unusual bleeding, bruising, or weakness).
- If your burn wounds do not heal or if they become worse, call your doctor.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
- Do not use this medicine for a skin problem that has not been checked by your doctor.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Change in how much or how often you urinate
- Fever, chills, cough, sore throat, and body aches
- Unusual bleeding, bruising, weakness
If you notice these less serious side effects, talk with your doctor:
- Changes in skin color
- Mild rash
- Skin discomfort when in sunlight