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Oxycodone/acetaminophen (By mouth)
Acetaminophen (a-seet-a-MIN-oh-fen), Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)
Treats moderate to moderately severe pain. This combination medicine contains a narcotic pain reliever.
There may be other brand names for this medicine.
Endocet, Roxicet, Percocet, Roxilox, Tylox, Magnacet, Oxycodone/APAP, Primlev, Primalev, Xolox
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to acetaminophen or oxycodone. You should not use Tylox® capsules if you are allergic to sulfites. You should not use this medicine if you have serious breathing problems (such as severe asthma) or a serious bowel problem called paralytic ileus.
How to Use This Medicine
Capsule, Liquid, Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- This combination medicine contains acetaminophen (Tylenol(R)). Carefully check the labels of all other medicines you are using because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).
- If this medicine upsets your stomach, you may take it with food or milk.
- Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
- Drink plenty of fluids to help avoid constipation.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Do not throw any unused medicine in the trash. Flush it down the toilet or take it to a community take-back program when available. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using atropine, butorphanol (Stadol®), dicyclomine (Bentyl®), glycopyrrolate (Robinul®), nalbuphine (Nubain®), naltrexone (Revia®), pentazocine (Talwin®), propranolol (Inderal®), scopolamine (Transderm Scop®), or a phenothiazine-type medicine (such as chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Phenergan®, or Thorazine®).
- Tell your doctor if you are using birth control pills (such as Nordette®, Norinyl®, Ortho-Novum®, Ovcon®, or Triphasil®), lamotrigine (Lamictal®), probenecid (Benemid®), zidovudine (Retrovir®), or a water pill (such as furosemide, torsemide, Demadex®, or Lasix®).
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
- Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver and drinking alcohol can increase this risk. If you regularly drink 3 or more alcoholic drinks every day, do not take acetaminophen without talking to your doctor first.
- Many combination medicines contain acetaminophen, including products with brand names such as Alka-Seltzer Plus®, Comtrex®, Drixoral®, Excedrin Migraine®, Midol®, Sinutab®, Sudafed® Nighttime Cold, Theraflu®, and Vanquish®. Carefully check the labels of all other medicines you are using to be sure they do not contain acetaminophen.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung disease (such as chronic obstructive pulmonary disease [COPD]), heart disease, low blood pressure, problems with urination, an underactive thyroid, Addison's disease, pancreas problems, prostate problems, or a stomach disorder. Tell your doctor if you have a history of head injury, brain tumor, psychosis (a mental disease), seizures, or alcohol or drug abuse. Make sure your doctor knows if you have ever had an allergy to codeine.
- This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
- This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Confusion, shortness of breath, or numbness or tingling in your hands, feet, or lips.
- Dark-colored urine or pale stools.
- Decrease in how much or how often you urinate.
- Extreme weakness, shallow breathing, irregular heartbeat, sweating, or cold or clammy skin.
- Fever, chills, cough, sore throat, and body aches.
- Increased hunger or thirst.
- Lightheadedness, dizziness, or fainting.
- Muscle pain, tenderness, or weakness.
- Nausea, vomiting, loss of appetite, or pain in the upper stomach.
- Tremors or seizures.
- Unusual bleeding or bruising.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Agitation, anxiety, or depression.
- Blurred vision or other changes in vision.
- Change in taste or unpleasant after taste.
- Constipation or diarrhea.
- Dry mouth.
- Feelings of extreme happiness or sadness.
- Hearing loss.
- Mild skin rash or itching.
- Sleepiness or unusual drowsiness.
- Trouble sleeping.
If you notice other side effects that you think are caused by this medicine, tell your doctor