Sulfadoxine/pyrimethamine (By mouth)


Pyrimethamine (pir-i-METH-a-meen), Sulfadoxine (sul-fa-DOX-een)
Treats or helps prevent malaria, an infection that can be serious, even life-threatening.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to any sulfa drug or to pyrimethamine. You should not use this medicine if you are breast feeding, or if you have megaloblastic anemia due to folate deficiency. This medicine should not be given to infants under 2 months of age.

How to Use This Medicine

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.This medicine should be taken after a meal. Swallow the tablet whole. Do not crush, break, or chew it.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
  • Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.
If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.Do not use two doses at the same time.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep all medicine away from children and never share your medicine with anyone.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also taking chloroquine (Aralen®), or sulfa antibiotics such as Cotrim®, Septra®, or Bactrim®.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have kidney problems, liver disease, or any blood problems. Tell your doctor if you have a history of folate (vitamin) deficiency, severe allergies, or asthma. Make sure your doctor knows if you have had an allergic reaction to a diuretic ("water pill") or a medicine taken by mouth to treat diabetes (high blood sugar).
  • If you develop a skin rash, stop taking this medicine immediately and see a doctor right away.
  • Becoming pregnant while using this medicine, or within three months after your last dose of this medicine, may harm your unborn baby. Use two forms of birth control to avoid getting pregnant while you are using this medicine. Keep using two forms for at least 3 months after your treatment ends.
  • If you are taking this medicine to keep from getting malaria, it is important that you also take other steps to protect yourself against the illness. Wear protective clothing, use insect repellants, and use bed nets to further decrease your risk of getting malaria. If you become ill and have a fever after returning from a malaria-prone area, call your doctor right away. Let your doctor know that you have been to an area where malaria infection is possible.
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Abdominal (belly) pain.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, or red skin rash, skin sores, or painful skin.
  • Chest pain or tightness, or an uneven heartbeat.
  • Eye pain, eyes sensitive to light, or eye discharge (pus or mucus).
  • Extreme tiredness.
  • Seizures or hallucinations (seeing or sensing things that are not there).
  • Sores in your mouth or throat.
  • Unexplained fever, sore throat, body aches, wheezing, or cough.
  • Unusual bleeding or bruising.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Diarrhea
  • Headache, ringing in your ears, or dizziness.
  • Irritability, nervousness, or other mood changes
  • Nausea, vomiting, or upset stomach.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
Adam Data Copyright The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only--they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

For information 410.787.4000

© 2015 UM Baltimore Washington Medical Center.  All rights reserved.

301 Hospital Drive, Glen Burnie, MD 21061 | 410-787-4000 | TTY 410-787-4498