Trimipramine Maleate (trye-MIP-ra-meen MAL-ee-ate)
Treats depression. Belongs to a class of drugs called tricyclic antidepressants.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to trimipramine or any other tricyclic antidepressant (such as Elavil®, Anafranil®, or Sinequan®). You should not take trimipramine if you have had a recent heart attack or have taken an MAO inhibitor drug (such as Eldepryl®, Parnate®, Nardil®, or Marplan®) within the past 14 days.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Your doctor may tell you to take this medicine at bedtime, because trimipramine can make you sleepy.
- It may take several weeks before you notice an improvement in your symptoms. Keep using this medicine as your doctor has told you. Do not stop using it without checking with your doctor first.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are taking cimetidine (Tagamet®), guanethidine (Ismelin®), thyroid medicine (such as levothyroxine, liothyronine, Cytomel®, Levoxyl®, or Synthroid®), medicine for heart rhythm problems (such as flecainide, propafenone, quinidine, Quinaglute®, Rythmol®, or Tambocor®), or phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®).
- Tell your doctor if you are also using other medicine to treat depression (such as fluoxetine, paroxetine, sertraline, Paxil®, Prozac®, or Zoloft®). You must wait at least 5 weeks between using this medicine and fluoxetine (Prozac®).
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, kidney disease, liver disease, thyroid problems, mental disorder (such as schizophrenia), or history of seizures, glaucoma, or problems with urination.
- For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor or your child's doctor right away if you or your child start to feel more depressed and have thoughts about hurting yourselves. Report any unusual thoughts or behaviors that trouble you or your child, especially if they are new or are getting worse quickly. Make sure the doctor knows if you or your child have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you or your child have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you, your child, or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
- This medicine may raise or lower your blood sugar, or it may cover up symptoms of very low blood sugar (hypoglycemia).
- This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Anxiety, agitation, restlessness, or mood or mental changes.
- Change in how much or how often you urinate, or problems with urination.
- Changes in behavior, or thoughts of hurting yourself or others.
- Chest pain or shortness of breath.
- Fast, slow, pounding, or irregular heartbeat.
- Lightheadedness or fainting.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Seizures or tremors.
- Severe confusion, or seeing or hearing things that are not there.
- Sudden or severe headache, problems with vision, speech, balance, or walking.
- Trouble sleeping or unusual dreams.
- Twitching or muscle movements you cannot control.
- Unexplained fever, chills, or sore throat.
- Unusual bleeding or bruising.
- Unusual tiredness or weakness.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Breast swelling and discharge in women.
- Drowsiness or dizziness.
- Dry mouth.
- Hair loss.
- Loss of appetite.
- Nausea, vomiting, diarrhea, constipation, or stomach cramps.
- Problems having sex.
- Ringing in the ears.
- Skin rash or itching.
- Sores or white patches on your lips, mouth, or throat.
- Swelling of the breasts or testicles in men.
- Warmth or redness in your face, neck, arms, or upper chest.
- Weight changes.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04