Ifosfamide (Injection)


Ifosfamide (eye-FOS-fa-mide)
Treats cancer of the testicles and many other types of cancers, often in combination with other medicine.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have ever had an allergic reaction to ifosfamide.

How to Use This Medicine

  • This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are getting it and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
  • Your doctor will prescribe your exact dose and tell you how often it will be given.
  • Your medicine will be given through a tube put in one of your veins, usually in your arm, wrist, or hand and sometimes in the chest. This is called intravenous (in-tra-VEEN-us), or IV.
  • A nurse or other care give trained to give cancer drugs will give your treatment.
  • Drink at least 8 full glasses of liquid the day before and the day of receiving your medicine, and every day for 3 days afterward.
  • Do not get the medicine on your skin. If it does, wash the area well with soap and water, and tell your caregiver.
If a dose is missed:
  • This medicine needs to be given on a regular schedule. If you miss a dose, call your doctor, home health caregiver, or clinic where you get your treatments for instructions.

How to Store and Dispose of This Medicine

  • If you have your treatments at a clinic, the staff at the clinic will keep your medicine there.
  • If you have your treatments at home, you may need to store your medicine. Keep the medicine at room temperature, away from heat, moisture, and direct light.
  • Any ifosfamide that has been mixed for an IV (mixed with other liquid) is good for 7 days at room temperature or 6 weeks if refrigerated. Keep the medicine in the refrigerator if possible, away from light and moisture.
  • Throw away any unused medicine if the expiration date has passed.
  • Keep all medicine out of the reach of children.
  • If you have your treatments at home, you should be given a special container for the used needles, medicine bags or bottles, and tubes. Put it where children or pets cannot reach it.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also taking allopurinol (Zyloprim®), chloral hydrate, phenobarbital, phenytoin (Dilantin®), cisplatin (Platinol®), corticosteroids, or succinylcholine.
  • Talk to your doctor before getting any vaccines (such as flu shots) while receiving ifosfamide.

Warnings While Using This Medicine

  • Do not breastfeed if you are being treated with this medicine.
  • Before using this medicine, tell your doctor if you have kidney problems, or if you have recently had other chemotherapy or radiation treatments.
  • You may get infections more easily while you are getting ifosfamide. Stay away from crowds or people with colds, flu, or other infections.
  • This medicine may make your mouth sore and irritated. Brush your teeth with a soft-bristle toothbrush or mouth swab.
  • This medicine can cause nausea and vomiting. Your doctor may prescribe medicine to keep you from feeling sick and throwing up. If the medicine does not help (you can't keep liquids down), call your doctor.
  • Do not get pregnant while you or your sexual partner are being treated with ifosfamide. Use an effective form of birth control while you are getting this medicine.
  • If you are pregnant, talk to your doctor before you start your treatments.
  • Some cancer drugs may make you sterile (unable to have children), whether you are a man or woman. If you plan to have children someday, talk with your doctor before you start your treatments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Pain or burning when going to the bathroom (urinating)
  • Bloody urine
  • Unexplained fever, chills, or sore throat
  • Unusual bleeding or bruising
  • Extreme tiredness, dizziness
  • Uncontrollable nausea, vomiting, or diarrhea
If you notice these less serious side effects, talk with your doctor:
  • Hair loss
  • Upset stomach, loss of appetite
  • Confusion
  • Weakness, drowsiness, feeling tired

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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