Doxorubicin hydrochloride liposome (Injection)

Introduction

Doxorubicin Hydrochloride Liposome (dox-oh-ROO-bi-sin hye-droe-KLOR-ide LYE-poh-some)

Treats Kaposi's sarcoma in patients who have human immunodeficiency virus (HIV). Also treats cancer of the ovary. This medicine may also be used together with bortezomib to treat multiple myeloma (blood plasma cell cancer).

Brand Name(s)

There may be other brand names for this medicine.

Doxil

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to doxorubicin, or if you are breastfeeding.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Take the medicine out of the refrigerator about an hour before your treatment and let it warm to room temperature.
  • Before your treatment, check your IV bag to make sure there are no leaks.
  • When you give the medicine, you should not use IV tubing that has a filter either attached or in-line.
  • Do not get the medicine on your skin. If this does happen, wash the area well with soap and water, and tell your caregiver.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

How to Store and Dispose of This Medicine

  • If you have your treatments at a clinic, the staff at the clinic will keep your medicine there.
  • If you have your treatments at home, you may need to store your medicine. You should receive your medicine already mixed and in an IV bag. You can keep the IV bag in the refrigerator for up to 24 hours. Do not freeze. After 24 hours, a new bag of medicine should be used.
  • Look at the liquid in the bag. It should be red in color. You should not use the medicine if it changes color or has lumps or solid pieces in it.
  • Keep all medicine away from children and never share your medicine with anyone.
  • If you have your treatments at home, you should be given a special container for the used needles, medicine bag or bottles, and tubes. Put it where children or pets cannot reach it.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines may become harmful when taken with doxorubicin liposomal (such as other anti-cancer drugs or radiation). Make sure you tell your doctor what other medicines you are taking.

Warnings While Using This Medicine

  • This medicine can cause birth defects if it is used by the mother while she is pregnant or by the father when his sexual partner becomes pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.
  • Tell your doctor if you have liver disease or heart disease (especially congestive heart failure, or CHF) before you receive this medicine. Also tell your doctor if you have had chemotherapy or radiation treatment in the past.
  • Tell your doctor if you have back pain, flushing in your face, shortness of breath, headache, swelling in your face, or a tight feeling in your chest or throat while you are having your treatment. You may be getting the medicine too fast or having a reaction to the medicine.
  • This medicine may turn your urine red for 1 or 2 days after your treatment. This is normal. You may need to protect your clothing from being stained.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Tell your doctor right away if you start to have swelling, pain, redness, or peeling of the skin on your hands and feet. Your doctor may need to change your dose of this medicine.
  • This medicine may make your mouth sore and irritated. Brush your teeth with a soft-bristle toothbrush or mouth swab.
  • Doxorubicin liposomal is made differently than regular doxorubicin (Adriamycin®). Some patients who were not helped by regular doxorubicin may have better results with doxorubicin liposomal. However, the liposomal form may cause different side effects than regular doxorubicin.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Your blood will also need to be checked frequently. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate, or painful urination.
  • Fast or irregular heartbeat, headache, chest pain.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Peeling skin, redness, and pain in your hands or feet.
  • Rapid weight gain or swelling of hands, ankles, or feet.
  • Redness, swelling, burning, or pain where the needle is placed.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Sores or white patches on your lips, mouth, or throat.
  • Uncontrollable vomiting or diarrhea.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
  • Warmth or redness in your face, neck, or chest.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Constipation, dry mouth, increased thirst.
  • Hair loss.
  • Mild stomach pain, nausea, loss of appetite.
  • Reddish-orange urine or other body fluids.
  • Skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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