Mirtazapine (By mouth)

Introduction

Mirtazapine (mir-TAZ-a-peen)

Treats depression.

Brand Name(s)

There may be other brand names for this medicine.

Remeron, Remeron Soltab

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to mirtazapine.

How to Use This Medicine

Tablet, Dissolving Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Your doctor may tell you to take the medicine at bedtime, because mirtazapine can make you sleepy. You may take this medicine with or without food.
  • You may need to take this medicine for several weeks before you begin to feel better.
  • If you are using the disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a drink of water. Do not keep a tablet to use later after you have removed it from the blister pack. Do not crush, split, or break the tablet.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the orally disintegrating tablet in the original package until you are ready to take it.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using a medicine for depression called a MAO inhibitor (such as isocarboxazid, phenelzine, selegiline, Eldepryl®, Marplan®, Nardil®, or Parnate®) in the past 2 weeks.
  • Make sure your doctor knows if you are using any medicines that make you sleepy, such as sedatives, sleeping pills, cold and allergy medicines, or narcotic pain killers.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, high cholesterol in the blood, or a history of seizures. Tell your doctor if you have any kind of heart or circulation problems, including low blood pressure, or a history of a heart attack or stroke.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or getting worse quickly. Make sure your doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also, tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance for getting an infection. If you can, avoid people with infections. Stop using this medicine and check with your doctor right away if you think you are getting an infection or if you have a fever or chills, sore throat, mouth sores, lower back or side pain, or painful or difficult urination.
  • This medicine may increase your weight. Your doctor may need to check your weight regularly during treatment with this medicine.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.
  • The orally disintegrating tablet contains phenylalanine. Tell your doctor if you have phenylketonuria (PKU) before taking the tablet.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate.
  • Chest pain or a heartbeat that is too slow or uneven.
  • Fever, chills, cough, sore throat, or body aches.
  • Lightheadedness, dizziness, or fainting.
  • Mouth sores.
  • Severe vomiting or diarrhea.
  • Swelling in your hands, ankles, or feet.
  • Tremors.
  • Unusual behaviors or thoughts of hurting yourself or others.
  • Unusual tiredness or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Constipation, stomach discomfort, or nausea.
  • Dry mouth or thirst.
  • Increased appetite or weight gain.
  • Odd or unusual dreams or thoughts.
  • Sleepiness or unusual drowsiness.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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