Treats rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn disease, plaque psoriasis, and ulcerative colitis.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not receive this medicine if you have had an allergic reaction to infliximab or murine (mouse) proteins. You should not receive high doses of this medicine if you have moderate to severe heart failure.
How to Use This Medicine
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
- A nurse or other trained health professional will give you this medicine.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
- This medicine needs to be given slowly. The needle will need to be in place for at least 2 hours. You may also receive medicines to help with side effects.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows about any other medicine you are using to treat your condition. This includes abatacept (Orencia®), anakinra (Kineret®), certolizumab (Cimzia®), etanercept (Enbrel®), golimumab (Simponi®), rituximab (Rituxan®), tocilizumab (Actemra®), or other biologics.
- Make sure your doctor knows if you use a medicine that weakens your immune system, such as methotrexate (Folex®, Rheumatrex®) or a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®).
- Tell your doctor if you also use cyclosporine (Gengraf®, Neoral®, Sandimmune®), theophylline (Theo-Dur®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
- You should not receive a live vaccine while you are being treated with this medicine. If this medicine is used by a child, that child should have all vaccines current before starting treatment.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, heart problems, diabetes, or a bleeding disorder. Tell your doctor if you have a history of seizures, multiple sclerosis, Guillain-Barré syndrome, or a similar nervous system disease.
- This medicine increases your risk of infection. Make sure your doctor knows if you have an infection. Also tell your doctor if you or anyone in your home has trouble with frequent infections, a weak immune system, history of tuberculosis or hepatitis B, or recently been on a trip. Call your doctor right away if you think you have an infection.
- Your doctor will test you for tuberculosis (TB) before you start using this medicine. Tell your doctor if you or anyone in your home has ever had a positive TB skin test.
- While you are being given this medicine, tell your health caregiver right away if you have a fever, chills, rash, nausea, dizziness, lightheadedness, headache, body aches, trouble breathing, or itching. These could be symptoms of an infusion reaction.
- A small number of people who have used this medicine have developed cancer. Make sure your doctor knows if you have had cancer before, if you have COPD (a lung disease), or if you have had light therapy for psoriasis. Talk to your doctor about your personal risk. Tell your doctor if you have swollen lymph nodes, unexplained weight loss, skin changes or growths, or unusual bleeding, bruising, or weakness. This could be more likely if you are also using steroid medicine or methotrexate.
- It is important to have your heart checked when you receive infliximab. Call your doctor right away if you have trouble breathing, swelling in the face, ankles, or feet, or a sudden weight gain.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
- Check with your doctor right away if you have a rash, unusual tiredness or weakness, joint or muscle pain, nausea and vomiting, or stomach pain. This medicine may rarely cause other problems with your immune system.
- If you are treated with this medicine while you are pregnant, make sure your baby's doctor knows this. Your baby has a higher risk of infection and should not receive live vaccines at first.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Infusion reaction: fever, chills, chest pain, headache, lightheadedness, nausea, trouble breathing, rash, itching
- Joint or muscle pain
- Lightheadedness, dizziness, or fainting
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- Seizures, problems with vision, speech, or walking
- Sore throat, cough, runny or stuffy nose, sneezing, chills, body aches
- Swelling in your hands, ankles, or feet
- Swollen glands
- Trouble breathing
- Unusual bleeding, bruising, tiredness, or weakness
- Warm, red, swollen, or painful skin, blisters, skin sores
If you notice these less serious side effects, talk with your doctor:
- Redness, pain, or swelling where the needle is placed
- Warmth or redness in your face, neck, arms, or upper chest