Lopinavir (loe-PIN-a-vir), Ritonavir (rit-OH-na-vir)
Treats human immunodeficiency virus (HIV) infection. HIV causes acquired immune deficiency syndrome (AIDS). This medicine does not cure HIV or AIDS, but combination of drugs may slow the progress of the disease.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had a severe allergic reaction to lopinavir or ritonavir. Do not use this medicine if you are also using alfuzosin (Uroxatral®), cisapride (Propulsid®), lovastatin (Advicor®, Altoprev®, Mevacor®), oral midazolam syrup (Versed®), pimozide (Orap®), rifampin (Rifadin®, Rimactane®), sildenafil (Revatio®), simvastatin (Simcor®, Vytorin®, Zocor®), St John's wort, triazolam (Halcion®), or an ergot medicine (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, Cafergot®, Migranal®).
How to Use This Medicine
Liquid Filled Capsule, Liquid, Tablet
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Children should not be given this medicine on a once-a-day schedule because it would give them too much medicine at one time. Children should have a schedule that splits the medicine into 2 or more doses.
- Tablet: You may take the tablet with or without food.
- Capsule or oral liquid: Take with food.
- Swallow the tablet whole. Do not crush, break, or chew it.
- Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
- Take all other medicines your doctor has prescribed as part of your combination treatment. Do not change your dose or stop using your medicine unless your doctor tells you to.
- This medicine works best if there is a constant amount in the blood. Take this medicine at the same time each day and do not miss any doses. Contact your doctor or pharmacist when your supply of this medicine is running low. Do not let your medicine run out.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Capsule or oral liquid: Store in the refrigerator or at room temperature. If you store the medicine at room temperature, it expires after 2 months.
- Tablet: Store at room temperature. Keep away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using other medicines to treat HIV/AIDS (such as abacavir, amprenavir, atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, maraviroc, nelfinavir, nevirapine, saquinavir, tenofovir, tipranavir, zidovudine, Atripla®, Crixivan®, Lexiva®, Reyataz®, Selzentry®, Sustiva®), medicine to treat seizures (such as carbamazepine, lamotrigine, phenobarbital, phenytoin, valproate, Dilantin®, Tegretol®), medicine to treat erectile dysfunction (such as avanafil, sildenafil, tadalafil, vardenafil, Adcirca®, Cialis®, Levitra®, Stendra®, Viagra®), medicine to treat a fungus infection (such as itraconazole, ketoconazole, voriconazole, Nizoral®), certain blood pressure medicines (such as atenolol, felodipine, metoprolol, nicardipine, nifedipine), medicine for heart rhythm problems (such as dofetilide (Tikosyn®), amiodarone, bepridil, digoxin, lidocaine, quinidine, Cardioquin®, Cordarone®, Lanoxin®), medicine to lower cholesterol (such as atorvastatin, rosuvastatin, Crestor®, Lipitor®), insulin or diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or a blood thinner (such as rivaroxaban, warfarin, Coumadin®, Jantoven®).
- Tell you doctor if you are also using atovaquone (Mepron®), bosentan (Tracleer®), bupropion (Wellbutrin®), clarithromycin (Biaxin®), colchicine (Colcrys®), fentanyl (Duragesic®, Sublimaze®), methadone (Dolophine®), rifabutin (Mycobutin®), salmeterol (Advair®, Serevent®), trazodone (Desyrel®), medicines that weaken the immune system (such as cyclosporine, sirolimus, tacrolimus, Gengraf®, Neoral®, Protopic®, Rapamune®, Sandimmune®), medicine to treat hepatitis C (such as boceprevir, telaprevir, Incivek®, Victrelis®), certain cancer medicines (such as dasatinib, nilotinib, vinblastine, vincristine, Oncovin®, Vincasar®), a steroid medicine (such as budesonide, dexamethasone, fluticasone, prednisone, Decadron®, Flonase®), or birth control pills.
- If you also use didanosine (Videx®), take it 1 hour before or 2 hours after taking Kaletra® capsules or oral liquid. Didanosine can be taken (without food) at the same time as Kaletra® tablets.
- The liquid form of this medicine contains alcohol. Tell your doctor if you use or plan to use disulfiram (Antabuse®) or metronidazole (Flagyl®).
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant, or if you have a history of liver disease (such as cirrhosis, hepatitis B or C), diabetes, pancreas problems, or hemophilia. Your doctor needs to know if you have high cholesterol or triglycerides in your blood or if you have a family history of these problems. Tell your doctor if you have a history of heart disease or heart rhythm problems, or have low potassium levels in the blood.
- You should not breastfeed if you have HIV or AIDS, because you might give the infection to your baby through your breast milk.
- This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV. Do not share needles with anyone.
- Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as PR or QT prolongation.
- Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis.
- This medicine may cause you to have excess body fat. Tell your doctor if you notice changes in your body shape, such as more fat in the upper back and neck, or around the chest and stomach area. You may also lose fat from the legs, arms, and face.
- Birth control pills that contain estrogen may not work as well while you are using this medicine. Use another form of birth control together with your pills to avoid getting pregnant. Other forms include condoms, a diaphragm, contraceptive foam, or jelly.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Change in how much or how often you urinate
- Chest pain or fast, pounding, or uneven heartbeat
- Dark-colored urine or pale stools, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Dizziness, lightheadedness, fainting
- Increased hunger or thirst
- Rapid weight gain, swelling in your hands, ankles, or feet
- Sudden and severe stomach pain, nausea, vomiting, fever, or lightheadedness
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, nausea, vomiting, stomach pain
- Lack or loss of strength
- Weight gain around your neck, upper back, breast, or waist