Lisinopril/hydrochlorothiazide (By mouth)

Introduction

Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Lisinopril (lye-SIN-oh-pril)

Treats high blood pressure (hypertension). This medicine is a combination of an angiotensin-converting enzyme (ACE) inhibitor and a diuretic ("water pill").

Brand Name(s)

There may be other brand names for this medicine.

Zestoretic, Prinzide

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to lisinopril (Zestril®, Prinivil®), hydrochlorothiazide (HCTZ), sulfa drugs (such as sulfamethoxazole/trimethoprim, Bactrim®, Septra®), or other blood pressure medicines (such as Accupril®, Altace®, Lotensin®, Lotrel®, Monopril®, or Zestoretic®). You should not use this medicine if you are pregnant, or if you have hereditary or idiopathic angioedema.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take this medicine with or without food.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using lithium, gold injections, or a diuretic ("water pill"), such as amiloride (Midamor®, Moduretic®), chlorthalidone (Thalitone®), eplerenone (Inspra®), furosemide (Lasix®), spironolactone (Aldactazide®, Aldactone®), or triamterene (Dyazide®, Dyrenium®, Maxzide®). Your doctor will need to know if you are using insulin or a diabetes medicine that you take by mouth, such as glipizide, glyburide, metformin, Actos®, Amaryl®, Avandia®, Glucotrol®, or Glucophage®. Tell your doctor if you are using a steroid medicine, such as dexamethasone, prednisolone, prednisone, or Medrol®.
  • Tell your doctor if you are using sleeping pills (such as lorazepam, Ativan®), narcotic pain relievers (such as acetaminophen/codeine, acetaminophen/oxycodone, acetaminophen/hydrocodone, Endocet®, Lorcet®, Percocet®, or Vicodin®), or a pain or arthritis medicine (such as aspirin, ibuprofen, naproxen, Advil®, Aleve®, Feldene®, or Voltaren®). Make sure your doctor knows if you are using a medicine to lower your cholesterol, such as cholestyramine (Questran®) or colestipol (Colestid®). You should not use medicines or salt substitutes that contain potassium (including supplements) without asking your doctor.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, heart disease, heart valve problems, liver disease, diabetes, gout, or lupus.
  • Tell your doctor about any allergic reaction you have had to any drug, especially if the reaction caused you to have swelling in your face, lips, tongue, or throat.
  • This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. Dizziness may be worse if you lose too much water from your body. You can lose water by sweating, having diarrhea, or vomiting. Tell your doctor if this medicine makes you feel lightheaded or dizzy after you have been vomiting or had diarrhea.
  • This medicine may raise your blood sugar. You should check your blood sugar more often during the first month you take this medicine, and then on a regular basis.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
  • If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, red skin rash.
  • Change in how much or how often you urinate.
  • Chest pain.
  • Confusion, body weakness, uneven heartbeat, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Dark-colored urine or pale stools.
  • Dry mouth, increased thirst, muscle cramps, problems urinating, or nausea or vomiting.
  • Fast, slow, or pounding heartbeat.
  • Fever, chills, sore throat, and body aches.
  • Lightheadedness, dizziness, fainting, shakiness, or hunger.
  • Nausea, vomiting, or abdominal pain.
  • Rapid weight gain.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Dry cough.
  • Headache.
  • Mild skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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