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Nateglinide (By mouth)
Lowers blood sugar in people who have Type 2 diabetes and are not using insulin.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to nateglinide, or if you are in diabetic ketoacidosis. This medicine is not for use in treating Type I (insulin-dependent) diabetes.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine within 30 minutes before a meal. If you skip a meal, then you should also skip your dose of nateglinide.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- There are many other drugs that can interact with nateglinide. Make sure your doctor knows about all other medicines you are using.
- Your doctor should know if you are also using pain or arthritis medicine (sometimes called "NSAIDs") such as ibuprofen, naproxen, Advil®, or Aleve® and salicylates such as aspirin. Tell your doctor if you are using an MAO inhibitor such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Make sure your doctor knows if you are using beta blockers such as atenolol, metoprolol, propranolol, or Toprol®.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breast feeding. Your doctor should know if you have kidney disease or liver disease.
- If your blood sugar gets too low, you may feel weak, drowsy, confused, anxious, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, or a headache that will not go away.
- If you have symptoms of low blood sugar (hypoglycemia), check your blood sugar. If your blood sugar is 70 mg/dL (milligrams per deciliter) or below, do one of the following: Drink 4 ounces (one-half cup) of fruit juice, or eat 5 to 6 pieces of hard candy, or take 2 or 3 glucose tablets. Recheck your blood sugar 15 minutes later. If your blood sugar goes above 70 mg/dL, eat a snack or a meal. If your blood sugar is still below 70 mg/dL, drink one-half cup juice, or eat 5 to 6 pieces of candy, or take 2 to 3 glucose tablets.
- Carry candy or some type of sugar with you at all times, especially if you are away from home. You can take this if you feel that your blood sugar is too low, even if you do not have a blood glucose meter. Always carefully follow your doctor's instructions about how to treat your low blood sugar.
- Learn what to do if your blood sugar gets too low. Teach friends, co-workers, and family members what they can to do help if you have low blood sugar.
- If you get sick, injured, or have surgery, this medicine may not work as well as usual. You may need other medicine in addition to nateglinide. Call your doctor for instructions.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Rapid weight gain.
- Swelling in your hands, ankles, or feet.
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, nausea.
- Stuffy or runny nose, cough, sneezing, sore throat.
If you notice other side effects that you think are caused by this medicine, tell your doctor