Sumatriptan (Injection)


Sumatriptan (soo-ma-TRIP-tan)
Treats migraine and cluster headaches.

Brand Name(s)

There may be other brand names for this medicine.

Imitrex Statdose Refill, Imitrex Statdose System, Imitrex STATdose, Imitrex, Sumavel DosePro, Imitrex Stat Dose Refill

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to sumatriptan. You should not use this medicine if you have a history of certain heart or blood vessel disorders, stroke, ischemic bowel disease, or severe liver disease. You should not receive this medicine if you have uncontrolled high blood pressure, or if you are also using an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®) within the past 14 days. Do not receive this medicine if you have taken other migraine medicines (such as almotriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan, Axert?, Frova®, Amerge®, Maxalt®, or Zomig®) or an ergotamine medicine (such as methysergide, D.H.E. 45®, or Migranal®) within the past 24 hours.

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • A nurse or other trained health professional will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • If your headache does not go away after using this medicine, do not use a second dose. Call your doctor for instructions.
  • If your headache goes away but comes back, a second dose may be needed. Wait at least 1 hour has passed since your first dose. If you feel you need to use the medicine more than 2 times in one day, call your doctor.
  • This medicine is available in 3 forms. You may use a single dose vial, prefilled syringe, or a prefilled autoinjector.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

How to Store and Dispose of This Medicine

  • If you store this medicine at home, keep it at room temperature, away from heat, moisture, and direct light.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also using medicine for depression (such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, olanzapine, paroxetine, sertraline, trazodone, venlafaxine, Celexa®, Cymbalta®, Effexor®, Lexapro®, Luvox®, Paxil®, Prozac®, Sarafem®, Serzone®, Symbyax®, or Zoloft®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant. Your doctor may want you to join a pregnancy registry for patients using this medicine.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, high blood pressure, high cholesterol, or a family history of coronary artery disease. Tell your doctor if you have bleeding problems, diabetes, or a history of seizures or epilepsy.
  • This medicine may increase your risk of having a heart attack or stroke. This is more likely to occur if you already have a heart disease, if you smoke, if you are over 40, or if you have gone through menopause. People who use this medicine for a long time might also have a higher risk.
  • Make sure your doctor knows about all the other medicines you are using. Sumatriptan may cause a serious condition called serotonin syndrome when taken with some medicines. Check with your doctor first before taking any other medicines.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once.
  • Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an eye doctor.
  • Check with your doctor right away if you have chest discomfort, jaw or neck tightness after receiving this medicine. Also, tell your doctor if you have sudden or severe abdominal or stomach pain after using this medicine.
  • This medicine may make you dizzy, drowsy, or less alert. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blurred vision or changes in vision.
  • Changes in color or sensation to your fingers and toes.
  • Chest pain or shortness of breath.
  • Fast, pounding, or uneven heartbeat.
  • Numbness or tingling in your hands, arms, legs, or feet.
  • Pain, itching, burning, swelling, or a lump under your skin where the shot is given.
  • Seeing, hearing, or feeling things that are not there.
  • Slurred speech.
  • Stomach pain, diarrhea, or blood in the stools.
  • Tightness or discomfort in your chest, neck, or jaw.
If you notice these less serious side effects, talk with your doctor:
  • Discomfort in the nose or throat.
  • Feeling of warmth or being too hot.
  • Feeling weak, drowsy, or tired.
  • Muscle weakness.
  • Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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