Tenofovir Disoproxil Fumarate (ten-OF-oh-vir dye-soe-PROX-il FUE-ma-rate)
Treats human immunodeficiency virus (HIV) infection. HIV causes acquired immune deficiency syndrome (AIDS). Tenofovir does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease. Also treats hepatitis B virus (HBV) infection.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to tenofovir.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Tenofovir is used with other medicines to treat HIV infection. Take all other medicines your doctor has prescribed as part of your combination treatment.
- Tell your doctor if you have trouble swallowing a pill. You might be able to use the oral powder.
- Oral powder:
- Measure the oral powder with the dosing scoop that comes with the package. If you have any questions about this, ask your doctor or pharmacist.
- Mix the oral powder with 2 to 4 ounces of soft food (such as applesauce, baby food, yogurt).
- Swallow this mixture right away. You are less likely to have a bitter taste if you take it as soon as it is mixed.
- Do not mix the oral powder with a liquid. The powder will not mix correctly and will float on top.
- Do not store the scoop inside the package with the powder.
- Keep taking this medicine for the full time of treatment, even if you begin to feel better. Do not change or stop using this medicine without checking first with your doctor.
- You should take this medicine every day and try not to miss any doses. Contact your doctor or pharmacist when your supply is running low. Do not allow yourself to run out of medicine.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the bottle tightly closed. Keep the medicine in the original bottle that you were given at the pharmacy.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using Atripla®, Complera®, Stribild?, or Truvada®. These medicines also contain tenofovir, and you would get too much medicine if you took them together.
- Make sure your doctor knows if you are also using adefovir (Hepsera®, acyclovir (Zovirax®), atazanavir (Reyataz®), cidofovir (Vistide®), didanosine (Videx®), ganciclovir (Cytovene®), lopinavir/ritonavir (Kaletra®), valacyclovir (Valtrex®), or valganciclovir (Valcyte®). Tell your doctor if you are using any medicines that may be hard on your kidneys.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant, or if you have kidney disease or liver disease.
- You should not breastfeed if you have HIV or AIDS, because you might give the infection to your baby through your breast milk.
- Two rare but serious reactions to this medicine are lactic acidosis (build-up of acid in the blood) and an enlarged liver. These are more common if you are female, very overweight (obese), or have been taking anti-HIV medicines for a long time. Call your doctor right away if you feel very tired, weak, or nauseated, if you vomit or have trouble breathing, or if your skin or eyes have turned yellow.
- Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections or disorders that were hidden in your body, such as Graves disease, Guillain-Barré syndrome, pneumonia, or tuberculosis.
- This medicine may cause you to have excess body fat. Tell your doctor if you notice changes in your body shape, such as an increased amount of fat in the upper back and neck, or around the chest and stomach area. You might also lose fat from the legs, arms, and face.
- This medicine might make your bones weak. You could be more likely to break a bone. Tell your doctor if you have osteoporosis or other bone problems. Call your doctor if you have bone pain or think you might have broken a bone.
- This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV. Do not share needles with anyone.
- Do not change your dose or stop taking this medicine, even for a short time, without talking to your doctor.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bone pain
- Change in how much or how often you urinate
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Extreme weakness, tiredness, or confusion
- Lightheadedness or fainting
- Rapid breathing or trouble breathing
If you notice these less serious side effects, talk with your doctor:
- Anxiety or depression
- Back pain
- Gaining weight around your neck, upper back, breast, face, or waist
- Headache or dizziness
- Mild nausea or diarrhea
- Mild rash