Oxaliplatin (Injection)

Introduction

Oxaliplatin (ox-al-i-PLA-tin)

Treats cancer of the colon or rectum when given with other cancer medicines such as 5-fluorouracil (5-FU)/leucovorin (LV).

Brand Name(s)

There may be other brand names for this medicine.

Eloxatin

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to oxaliplatin or similar medicines such as carboplatin, cisplatin, Paraplatin®, or Platinol®. You should not receive this medicine if you are pregnant.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • If any of this medicine gets on your skin or in your eyes, nose, or mouth, tell your doctor or nurse right away.
  • Oxaliplatin is usually used with other medicines to treat cancer. This combination of medicines is usually given for 2 days, but you will receive oxaliplatin on the first day only (day 1). This 2-day treatment is given again every 14 days until your body responds to the medicine.
  • You may also receive medicines to help prevent nausea and vomiting before treatment with oxaliplatin.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using a blood thinner such as warfarin (Coumadin®), or other medicines to treat cancer.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, lung or breathing problems, or nerve problems.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; chest pain; hives; hoarseness; itching; lightheadedness, dizziness, or fainting; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive the medicine.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Avoid cold temperatures and cold objects. Cold may cause or worsen some of the common side effects of this medicine. Do not use ice or drink cold beverages. Always wear gloves when touching anything cold, including metal or items in your refrigerator and freezer. Cover your skin, nose, and mouth if you must go outside in cold weather. You may need to wear long sleeves and pants if you are inside an air-conditioned car or room.
  • Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral or sensory neuropathy.
  • Stop using this medicine and check with your doctor right away if you start coughing, having shortness of breath, or any problems with breathing. These may be signs of a serious lung disease.
  • Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well. If these reactions are especially bothersome, check with your doctor.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, or red skin rash.
  • Change in how much or how often you urinate.
  • Clumsiness, unsteadiness, or trouble with normal daily activities such as writing.
  • Confusion, weakness, and muscle twitching.
  • Dark-colored urine or pale stools.
  • Dry cough, noisy breathing, or shortness of breath.
  • Dry mouth or increased thirst, muscle cramps, or ongoing or severe diarrhea or vomiting.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Numbness, tingling, or burning pain in your hands, arms, legs, feet, mouth, or throat.
  • Pain, redness, burning, swelling, or skin changes where the needle was placed.
  • Seizures or tremors.
  • Sudden or severe headache, problems with vision, hearing, speech, or walking.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Anxiety, depression, or trouble sleeping.
  • Back pain.
  • Blurred vision or changes in vision.
  • Constipation, diarrhea, stomach pain or upset, or loss of appetite.
  • Feeling sensitive to cold objects or cold temperatures.
  • Hair loss, mild skin problems, or increased sweating.
  • Jaw pain or tightness, trouble swallowing.
  • Joint pain or muscle weakness.
  • Mild headache.
  • Nosebleeds.
  • Runny or stuffy nose.
  • Sores or white patches on your lips, mouth, or throat.
  • Tiredness.
  • Unusual taste in your mouth.
  • Warmth or redness in your face, neck, arms, or upper chest.
  • Weight changes.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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