Rosuvastatin (By mouth)

Introduction

Rosuvastatin (roe-soo-va-STAT-in)

Lowers high levels of cholesterol and triglycerides (fats) in your blood. Used in combination with a diet program to help keep atherosclerosis (hardening of the arteries) from getting worse. Prevents stroke and heart attacks in older adults without known heart disease. This medicine is an HMG-CoA inhibitor, and is sometimes called a "statin."

Brand Name(s)

There may be other brand names for this medicine.

Crestor

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to rosuvastatin or to similar medicines such as atorvastatin (Lipitor®), fluvastatin (Lescol®), lovastatin (Mevacor®), pravastatin (Pravachol®), or simvastatin (Zocor®). You should not use this medicine if you have an active liver disease, or if you are pregnant or breastfeeding.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take this medicine with or without food.
  • Swallow the tablets whole. Do not break, crush, or chew it.
  • Carefully follow your doctor's instructions about diet and exercise. This medicine is only part of a complete plan for lowering cholesterol and triglycerides in your blood.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.However, do not take 2 doses of this medicine within 12 hours.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using birth control pills, cimetidine (Tagamet®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Lanoxin®), atazanavir/ritonavir, lopinavir/ritonavir (Kaletra®), niacin, spironolactone (Aldactone®), a blood thinner (such as warfarin or Coumadin®), an antibiotic (such as ketoconazole, itraconazole, fluconazole, erythromycin, Nizoral®, or Sporanox®), or other medicine for lowering cholesterol (such as fenofibrate, gemfibrozil, Lopid®, or Lipanthyl®).
  • If you need to take an antacid that contains aluminum and magnesium (such as Maalox®), take the antacid at least 2 hours after you take rosuvastatin.
  • Tell your doctor if you usually drink large amounts of alcohol.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you have kidney disease, an underactive thyroid, or a history of liver disease. Tell your doctor if you have a history of muscle pain or weakness.
  • Tell your doctor if you are of Asian descent, having either Filipino, Chinese, Japanese, Korean, Vietnamese, or Asian-Indian origin. You may need a slightly different dose of this medicine.
  • Call your doctor right away if you start to have unexplained muscle pain, tenderness, or weakness especially if with general feeling of discomfort or illness, fever, or dark-colored urine.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine if you have major surgery or a major injury (trauma). You also may need to stop if you develop other serious health problems, such as seizures or problems with your blood.
  • Do not stop or change your dose without checking first with your doctor, even if you are feeling well.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Chest pain.
  • Dark-colored urine or pale stools.
  • Decrease in how much or how often you urinate.
  • Fever, chills, cough, sore throat, and body aches.
  • Muscle pain, tenderness, weakness, or cramps.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Painful urination.
  • Swelling in your hands, ankles, or feet.
  • Unusual tiredness or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Headache or dizziness.
  • Joint pain.
  • Mild stomach upset, constipation.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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