Argatroban (Injection)

Introduction

Argatroban

Treats or prevents blood clots in patients with bleeding problems caused by another medicine called heparin. Also given to patients before having balloon angioplasty, a procedure to open a clogged artery.

Brand Name(s)

There may be other brand names for this medicine.

Novaplus Argatroban

When This Medicine Should Not Be Used

You should not receive this medicine if you have ever had an allergic reaction to argatroban. This medicine should not be given if you have severe bleeding from any cause.

How to Use This Medicine

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • This medicine is given in a hospital. A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using a blood thinner (such as warfarin or Coumadin®), streptokinase (Streptase®), aspirin, or other medicines that affect blood platelets (such as dextran, dipyridamole, hydroxychloroquine, ibuprofen, indomethacin, phenylbutazone, Advil®, Aggrenox®, InfeD®, Indocin®, Motrin®, Persantine®, or Plaquenil®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have hemophilia or any other bleeding problem. Also tell your doctor if you have a stomach or intestinal ulcer, liver disease, very high blood pressure, or if you have had a stroke or recent surgery or procedure on your eyes, brain, or spine.
  • You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
  • Watch for any bleeding from open areas such as around the injection site. Also check for blood in your urine or stool. If you have any bleeding or injuries, tell your doctor right away.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Black, tarry stools.
  • Chest pain, shortness of breath, or coughing up blood.
  • Fast, slow, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness or fainting.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Red or dark brown urine.
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Unusual bleeding, bruising, or weakness.
  • Vomiting of blood or material that looks like coffee grounds.

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, or vomiting.
  • Mild bleeding, itching, or rash where the needle is placed.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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