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You should not use this medicine if you have had an allergic reaction to tranylcypromine. Do not use this medicine if you have high blood pressure, liver disease, heart disease, or severe kidney disease. Do not use this medicine if you have severe or frequent headaches, or pheochromocytoma (a tumor of the adrenal gland). You should not use this medicine if you have ever had a stroke, transient ischemic attack (TIA), or any other kind of cerebrovascular disease.There are many medicines that you should not use while you are using tranylcypromine. This includes medicine you can buy without a prescription (over-the counter). Make sure your doctor knows about all other medicines you are using.If you were using another MAO inhibitor (such as isocarboxazid, phenelzine, selegiline, Eldepryl®, Emsam®, Marplan®, or Nardil®) for your depression, you must wait at least 7 days before you can start using tranylcypromine.If you were using fluoxetine (Prozac®) for your depression, you must wait at least 5 weeks before you can start using tranylcypromine. Also, you must wait at least 2 weeks between using this medicine and paroxetine (Paxil®) or sertraline (Zoloft®).If you stop using tranylcypromine, you must wait at least 7 days before starting another medicine for your depression. Some medicines for depression include amitriptyline, amoxapine, carbamazepine, clomipramine, cyclobenzaprine, desipramine, doxepin, imipramine, maprotiline, mirtazapine, nortriptyline, perphenazine, protriptyline, trimipramine, Anafranil®, Asendin®, Aventyl®, Carbatrol®, Elavil®, Flexeril®, Ludiomil®, Norpramin®, Pamelor®, Remeron®, Sinequan®, Surmontil®, Tegretol®, Tofranil®, Trilafon®, or Vivactil®.If you stop using tranylcypromine, you must wait at least 14 days before starting bupropion (Wellbutrin®, Zyban®) or fluoxetine (Prozac®). You must wait at least 10 days between using this medicine and buspirone (Buspar®). You must wait at least 2 or 3 weeks between using this medicine and meperidine (Demerol®).You should not use this medicine if you are also using an amphetamine (Desoxyn®, Dexedrine®), levodopa (Dopar®, Larodopa®), methyldopa (Aldomet®), reserpine (Harmonyl), or tryptophan. Do not use this medicine if you are using bupropion (Wellbutrin®), dextromethorphan (Benylin®), or meperidine (Demerol®).You should not use this medicine if you are also using citalopram (Celexa®), dexfenfluramine (Redux®), fluvoxamine (Luvox®), guanethidine (Ismelin®), paroxetine (Paxil®), sertraline (Zoloft®), or venlafaxine (Effexor®).