Heparin/sodium chloride premix (Injection)


Heparin (HEP-a-rin), Sodium Chloride (SOE-dee-um KLOR-ide)
Prevents clots in blood vessels before or after surgery or during certain medical procedures. Also treats certain blood, heart, and lung disorders and helps diagnose and treat certain bleeding disorders.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to heparin, or if you have active bleeding or severe thrombocytopenia (low platelet count in the blood).

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.
  • You may need to carry identification to let others know you are using heparin in case of an emergency. Ask your doctor about this.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are using a blood thinner (such as dicumarol, warfarin, Coumadin®), aspirin, or other medicine that affects blood platelets (such as dextran, dipyridamole, hydroxychloroquine, ibuprofen, indomethacin, phenylbutazone, Advil®, Aggrenox®, InfeD®, Indocin®, Motrin®, Persantine®, Plaquenil®).
  • Tell your doctor if you are also using digoxin (Lanoxin®, Digitek®), nicotine (Habitrol®, Nicoderm®, Prostep®), nitroglycerin injection, allergy medicine (such as diphenhydramine, Benadryl®), or certain antibiotic medicines (such as tetracycline, doxycycline, minocycline, Minocin®, Vibramycin®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have recently had a baby. Also tell your doctor if you have your monthly period or if you use an IUD for birth control.
  • Tell your doctor if you have heart disease (such as a heart infection), high blood pressure, a bleeding problem (such as hemophilia), stomach or intestinal ulcers, diabetes, kidney disease, liver disease, or if you have recently had any type of surgery or spinal anesthesia (numbing medicine in your back), radiation treatments, or a fall or other injury.
  • You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
  • Watch for any bleeding from open areas such as around the injection site. Also check for blood in your urine or stool. If you have any bleeding or injuries, tell your doctor right away.
  • Serious side effects can occur even up to several weeks after you have stopped using this medicine. Check with your doctor right away if you have any unusual side effects while you are using this medicine or after you stop using this medicine.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Bloody, black, tarry stools.
  • Chest pain, shortness of breath, or coughing up blood.
  • Increased menstrual bleeding.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in your lower leg (calf).
  • Prolonged and painful erection of the penis.
  • Red or dark brown urine.
  • Redness, pain, swelling, itching, blistering, sores, or rash where the needle is placed.
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Unexplained nosebleeds.
  • Unusual bleeding, bruising, or weakness.
  • Vomiting of blood or material that looks like coffee grounds.
  • Wheezing.
If you notice these less serious side effects, talk with your doctor:
  • Bone or joint pain.
  • Hair loss.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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