Mycophenolate mofetil (Injection)


Mycophenolate Mofetil Hydrochloride
Used with other medicines to keep your body from rejecting an organ transplant (heart, kidney, or liver). This medicine suppresses your immune system.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to mycophenolate, mycophenolic acid, or polysorbate 80. Do not receive this medicine if you are pregnant or breastfeeding. You should not receive this medicine if you are able to use the oral (pill or liquid) form of mycophenolate mofetil.

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.
  • This medicine must be given slowly, so the needle will remain in place for at least 2 hours.
  • If this medicine gets on your skin, wash the area with soap and water, and tell your caregiver. If you get the medicine in your eyes, nose, or mouth, rinse the area with large amounts of water, and tell your caregiver.
  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any questions about this, talk to your doctor.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also using acyclovir (Zovirax®), azathioprine (Imuran®), ganciclovir (Cytovene®, Vitrasert®), rifampin (Rifadin®, Rimactane®), sevelamer (Renagel®, Renvela?), valacyclovir (Valtrex®), valganciclovir (Valcyte®), medicine to treat an infection (such as amoxicillin/clavulanate, ciprofloxacin, erythromycin, metronidazole, norfloxacin, trimethoprim/sulfamethoxazole, Augmentin®, Bactrim?, Bactrim DS?, Biaxin®, Cipro®, Flagyl®, or Noroxin®), or medicines to treat high cholesterol (such as cholestyramine, colesevelam, colestipol, Colestid®, Questran®, Prevalite®, or Welchol®).
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving this medicine. Vaccines may not work as well, or they could make you ill while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. You must have a negative blood or urine pregnancy test before you start using the medicine to make sure that you are not pregnant. Birth control pills may not work as well while you are using this medicine. To keep from getting pregnant, use an additional form of birth control together with your pills, such as a condom, diaphragm, or contraceptive foam or jelly. Use the two forms of birth control beginning 4 weeks before you take this medicine, and continue them while you are using this medicine and for 6 weeks after your treatment ends. Tell your doctor right away if you think you have become pregnant while using the medicine.
  • Make sure your doctor knows if you have kidney disease, bone marrow problems, high blood pressure, stomach ulcers or bleeding, or a rare genetic disease called Lesch-Nyhan or Kelley-Seegmiller syndrome.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
  • You may be more likely to get infections while using this medicine. Tell your doctor if you have symptoms of an infection, such as fever or chills. Try to stay away from people with colds, flu, or other infections.
  • This medicine may increase your risk of developing a serious brain infection called progressive multifocal leukoencephalopathy (PML). Call your doctor right away if you are having more than one of these symptoms: vision changes, loss of coordination, clumsiness, memory loss, difficulty with speaking or understanding what others say, or weakness in the legs.
  • Using this medicine may increase your risk of getting skin cancer or cancer of the lymph system. Talk to your doctor if you have concerns about this risk.
  • Use a strong sunscreen (SPF-30 or higher) on your skin when you are outdoors. You should also wear a hat and cover your skin with clothing. Avoid sunlamps and tanning beds.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • This medicine may increase your risk of developing a rare and serious virus infection called BK virus-associated nephropathy (BKVAN). The BK virus may affect how your kidneys work and cause a transplanted kidney to fail. Check with your doctor right away if you are having more than one of these symptoms: bloody urine; a decreased frequency or amount of urine; increased thirst; loss of appetite; lower back or side pain; nausea; swelling of the face, fingers, or lower legs; trouble with breathing; unusual tiredness or weakness; vomiting; or weight gain.
  • This medicine may cause pure red cell aplasia (PRCA). This is a very rare condition where the body no longer makes red blood cells and the patient has severe anemia. Check with your doctor right away if you have a fever and sore throat; pale skin; unusual bleeding or bruising; or unusual tiredness or weakness.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Bloody, black, or tarry stools.
  • Blurred vision or other vision changes.
  • Change in how much or how often you urinate, or painful urination.
  • Difficulty with speaking or understanding what others say, or memory loss.
  • Dry mouth, increased thirst, or muscle cramps.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Loss of coordination, clumsiness, or weakness in your legs.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Severe stomach pain, bloody vomit or vomit that looks like coffee grounds.
  • Sores or white patches on your lips, mouth, or throat.
  • Swelling in your hands, ankles, or feet.
  • Tremors.
  • Trouble breathing, chest pain, or fast heartbeats.
  • Unusual bruising, bleeding, or weakness.
If you notice these less serious side effects, talk with your doctor:
  • Anxiety.
  • Diarrhea, constipation, nausea, vomiting, or indigestion.
  • Headache.
  • Joint or muscle pain.
  • Loss of appetite.
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
  • Runny or stuffy nose.
  • Skin rash.
  • Trouble with sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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