Conjugated estrogens (Injection)


Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz)
Treats abnormal bleeding from your uterus caused by a hormonal imbalance.

Brand Name(s)

There may be other brand names for this medicine.

Premarin Intravenous

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to conjugated estrogens or if you are pregnant. You should not use this medicine if you have had a recent stroke, blood clot, or heart attack. You should not use this medicine if you have cancer of the breast, uterus, or ovaries. You should not use this medicine for uterine bleeding that has not been checked by your doctor. You should not use this medicine if you have liver disease.

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins or given as a shot into one of your muscles.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
  • A nurse or other trained health professional will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Use a new needle and syringe each time you inject your medicine.
  • This medicine is not for long-term use.
If a dose is missed:
  • Call your doctor or pharmacist for instructions.

How to Store and Dispose of This Medicine

  • If you store this medicine at home, keep it in the refrigerator. Do not freeze.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • There are many other drugs that can interact with this medicine. Make sure your doctor knows about all other medicines you are using. This includes herbs, vitamins, supplements and medicines you can buy without a prescription (over-the counter).
  • Make sure your doctor knows if you are using medicine for fungal infection such as ketoconazole, itraconazole, or Nizoral®. Tell your doctor if you are using medicine to treat HIV or AIDS such as ritonavir (Norvir®). Make sure your doctor knows if you are using rifampin (Rifadin®, Rifater®), or St. John's Wort.
  • Make sure your doctor knows if you are using medicine to treat infection such as erythromycin (Ery-tab®) or clarithromycin (Biaxin®). Tell your doctor if you are using medicine for seizures such as phenobarbital or carbamazepine (Tegretol®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breast feeding.
  • Tell your doctor if you have high blood pressure, thyroid disease, diabetes, gallbladder problems, or heart disease.
  • Make sure your doctor knows if you have asthma, bone disease, cancer, epilepsy, endometriosis, fibroids in your uterus (womb), kidney disease, lupus, or migraine headaches.
  • Tell your doctor if you have a family history of breast cancer or high cholesterol or triglycerides.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine may increase your risk of cancer of the breast or uterus. Talk with your doctor about this risk.
  • This medicine should not be used to prevent heart disease. It may actually increase your risk of heart attack or stroke. This risk is even greater if you smoke.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Chest pain, shortness of breath, or coughing up blood.
  • Dark-colored urine or pale stools.
  • Lightheadedness or fainting.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in your lower leg (calf).
  • Sudden severe headache, problems with vision, speech, or walking.
  • Sudden and severe stomach pain, nausea, vomiting, and fever.
  • Swelling in your hands, ankles, or feet.
  • Sudden, severe pain in your eyes, or blurred vision.
  • Uterine cramps or increased bleeding.
  • Yellowing of your skin, or whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Change in hair growth on our face, chest, or arms.
  • Depression, dizziness, or nervousness.
  • Darkening of your skin on your face, hair loss on your scalp.
  • Increase or decrease in your body weight.
  • Pain or swelling in your breasts.
  • Pain, itching, swelling, or rash where the needle is placed.
  • Vaginal itching or discharge.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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