Physostigmine salicylate (Injection)


Physostigmine Salicylate (fye-soe-STIG-meen sa-LIS-i-late)
Treats drug overdose. Reverses the effects of certain kinds of drugs.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to physostigmine salicylate, sulfite, or benzyl alcohol. You should not receive this medicine if you have asthma, diabetes, heart disease, gangrene, or a blockage of the urinary or digestive tract. You should not receive this medicine if you are also receiving atropine, decamethonium, or succinylcholine.

How to Use This Medicine

  • A nurse or other trained health professional will give you this medicine.
  • This medicine is given through a needle placed in one of your veins, or as a shot into one of your muscles.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have asthma.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Increased watering in your mouth, severe nausea, or vomiting.
  • Increase in how much or how often you urinate, or severe diarrhea.
  • Seizures.
  • Slow heartbeat, dizziness, or fainting.
If you notice these less serious side effects, talk with your doctor:
  • Increased sweating.
  • Nausea or stomach pain.
  • Pain, itching, burning, or swelling, or a lump under your skin where the shot is given.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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