Ziconotide (Into the fluid around your spinal cord and brain)


Ziconotide (zye-KON-oh-tide)
Relieves severe chronic pain.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to ziconotide. You should not receive this medicine if you have a history of mental illness. Your doctor or health care giver will decide if there is any reason you should not receive this medicine.

How to Use This Medicine

  • A nurse or other trained health professional will give you this medicine.
  • This medicine is given as an injection into your spine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.
  • Make sure your doctor knows if you are also using antidepressants (such as amitriptyline, doxepin, nortriptyline, Celexa®, Pamelor®, Prozac®, Serzone®, Sinequan®, Zoloft®), sedatives such as diazepam, Librium®, Valium®, alprazolam, midazolam, Halcion®, Versed®, Xanax®), or antiepileptics (such as phenytoin, primidone, Dilantin®, Tegretol®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Abnormal vision.
  • Confusion or disorientation.
  • Dark-colored urine.
  • Decrease in how much or how often you urinate.
  • High fever or headache.
  • Lightheadedness or fainting.
  • Muscle pain, soreness, or weakness.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Seeing things that aren't there.
  • Seizures.
  • Severe vomiting.
  • Stiffness of your neck.
  • Suicidal thoughts.
If you notice these less serious side effects, talk with your doctor:
  • Abnormal thinking or anxiety.
  • Change in your mood.
  • Decreased alertness.
  • Dizziness.
  • Dry skin or rash on your skin.
  • Headache.
  • Loss of appetite.
  • Loss of memory.
  • Pain, swelling, itching, or burning where the shot was given.
  • Problems with balance or walking.
  • Problems with speech.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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