Exenatide (Injection)


Exenatide (ex-EN-a-tide)
Used alone or together with other medicines to treat type 2 diabetes. This medicine is used together with proper diet and exercise to help control your blood sugar.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to exenatide.

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • This medicine comes in a prefilled pen that you will use to inject it. Each pen contains enough medicine for 60 doses.
  • Use this medicine twice daily, unless your doctor tells you otherwise. You will need a shot within 1 hour (60 minutes) before your morning meal and 1 hour before your evening meal. Never use this medicine after a meal.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
  • Carefully follow your doctor's instructions about any special diet.
If a dose is missed:
  • You may use the medicine at any time within the 1-hour period before your morning or evening meal. If you forget to use the medicine before the meal, do not use it after you eat. Wait until the 1-hour period before your next morning or evening meal and use the medicine at that time. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store your new, unused medicine pen in the refrigerator. Protect it from light and keep it in the original carton. Do not freeze this medicine, and do not use the medicine if it has been frozen.
  • After using the medicine pen for the first time, you may store it in a closed container at room temperature. Keep it away from heat and protect it from light.
  • Remove the needle from the pen before you store the medicine. If the needle is left on the pen, medicine may leak from the pen or air bubbles may form in the cartridge.
  • Throw the pen away after using it for 30 days, even if there is some medicine left in it.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Tell your doctor if you are also using birth control pills or an antibiotic. These medicines should be taken at least 1 hour before you use exenatide.
  • Make sure your doctor knows if you are using acetaminophen (Tylenol®) or a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, stomach problems, or a history of pancreatitis.
  • This medicine does not work like insulin and should not be used to treat type 1 diabetes or diabetic ketoacidosis.
  • If your blood sugar gets too low, you may feel weak, drowsy, confused, anxious, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, or a headache that will not go away. If you have symptoms of low blood sugar (hypoglycemia), check your blood sugar. If your blood sugar is 70 mg/dL (milligrams per deciliter) or below, do one of the following: Drink 4 ounces (one-half cup) of fruit juice, or eat 5 to 6 pieces of hard candy, or take 2 to 3 glucose tablets. Recheck your blood sugar 15 minutes later. If your blood sugar goes above 70 mg/dL, eat a snack or a meal. If your blood sugar is still below 70 mg/dL, drink one-half cup juice, or eat 5 to 6 pieces of candy, or take 2 to 3 glucose tablets. Carry candy or some type of sugar with you at all times, especially if you are away from home. You can take this if you feel that your blood sugar is too low, even if you do not have a blood glucose meter. Always carefully follow your doctor's instructions about how to treat your low blood sugar. Learn what to do if your blood sugar gets too low. Teach friends, coworkers, and family members what they can do to help if you have low blood sugar.
  • This medicine may cause acute pancreatitis (swelling of the pancreas). Check with your doctor right away if you have severe stomach pain, nausea, or vomiting while you are using exenatide.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Burping or belching that causes burning in your throat.
  • Extreme weakness, confusion, or hunger.
  • Severe stomach pain, nausea, or vomiting.
If you notice these less serious side effects, talk with your doctor:
  • Dizziness or headache.
  • Feeling restless or jittery.
  • Mild nausea or vomiting, diarrhea, or stomach upset.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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