Pregabalin (By mouth)


Pregabalin (pre-GA-ba-lin)
Treats nerve pain caused by diabetes or herpes zoster (shingles). Also treats partial onset seizures in adults and fibromyalgia (muscle pain and stiffness).

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to pregabalin.

How to Use This Medicine

Capsule, Liquid
  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • This medicine is sometimes taken twice daily and sometimes three times daily. Your dose of this medicine will depend on the condition you are treating. Carefully follow your doctor's instructions for taking the medicine.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
  • You may take this medicine with or without food.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.
  • Pregabalin may be used together with other seizure medicines. Keep using all of your medicines unless your doctor tells you to stop.
If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Use the oral liquid within 45 days after opening the bottle. Throw away any unused medicine after 45 days.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also using diabetes medicine that you take by mouth (such as pioglitazone, rosiglitazone, Actos®, Avandamet®, or Avandia®) or certain blood pressure medicine (such as enalapril, lisinopril, Accupril®, Lotrel®, or Zestril®). Tell your doctor if you are also using a pain medicine (such as oxycodone, OxyContin®) or medicine for anxiety (such as lorazepam, Ativan®).
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant, or if you have kidney disease, congestive heart failure or other heart conditions, cancer, depression, diabetes, a bleeding disorder, or if you are on dialysis. Tell your doctor if you have had a history of alcohol or drug abuse.
  • This medicine may cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.
  • Do not breastfeed while you are using this medicine.
  • Stop using this medicine and call your doctor right away if you have swelling of the face, eyes, lips, gums, or tongue, or problems with swallowing or breathing. Also tell your doctor if you have hives or a skin rash, redness, or blisters while you are using this medicine. You may be having a serious allergic reaction or a condition called angioedema.
  • This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.
  • Unless you are using this medicine to treat diabetic neuropathy, make sure your doctor knows if you have diabetes. Check your skin regularly for changes or new skin ulcers.
  • This medicine may make you dizzy or drowsy. It may also cause problems with your vision. If these effects happen, avoid driving, using machines, or doing anything else that could be dangerous if you are not alert or able to see well.
  • This medicine may cause you to keep extra fluid in your body or cause you to gain weight. If this side effect is bothersome, check with your doctor.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blurred vision or any changes in vision.
  • Chest pain.
  • Confusion, trouble concentrating, or unusual thoughts or behavior.
  • Fever, chills, cough, sore throat, and body aches.
  • Muscle pain, soreness, or weakness with fever.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Problems with speech, balance, or walking.
  • Rapid weight gain, or swelling in your hands, ankles, or feet.
  • Severe dizziness or drowsiness.
  • Tremors.
  • Twitching or muscle movements you cannot control.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
If you notice these less serious side effects, talk with your doctor:
  • Dry mouth, constipation, or upset stomach.
  • Headache, runny or stuffy nose.
  • Increase in appetite.
  • Joint pain.
  • Mild skin rash or itching.
  • Problems with memory.
  • Problems with sex, loss of interest in sex.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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