Introduction

Conivaptan

Treats a condition in which there is low blood sodium with a normal blood volume.

Brand Name(s)

There may be other brand names for this medicine.

Vaprisol

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to conivaptan, if you have any other kind of low blood sodium, or if you are using certain antibiotics such as ketoconazole, itraconazole, clarithromycin, ritonavir, or indinavir.

How to Use This Medicine

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.Your dose may need to be changed several times in order to find out what works best for you.
• A nurse or other trained health professional will give you this medicine.
• This medicine is not for long-term use.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• There are many other drugs that can interact with conivaptan. Make sure your doctor knows about all other medicines you are using. These especially include ketoconazole, itraconazole, clarithromycin, ritonavir, or indinavir. Tell your doctor if you are also using midazolam, simvastatin, or digoxin (such as Lanoxin® or Digitek®).

Warnings While Using This Medicine

• Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, or heart disease.
• If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
• Dry mouth, increased thirst, muscle cramps, nausea or vomiting.
• Headache, lightheadedness, dizziness, or fainting.
• Severe weakness, or tingling or numbness on hands, feet or lips.
• Swelling in your hands, ankles, or feet.

If you notice these less serious side effects, talk with your doctor:

• Change in how much or how often you urinate.
• Diarrhea or constipation.
• Pain, itching, burning, swelling, or a lump under your skin where the shot is given.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088