Omeprazole/sodium bicarbonate (By mouth)


Omeprazole (oh-MEP-ra-zole), Sodium Bicarbonate (SOE-dee-um bye-KAR-bo-nate)
Treats heartburn, stomach ulcers (such as duodenal ulcer or gastric ulcer), gastroesophageal reflux disease (GERD), and also helps heal the esophagus when the stomach makes too much acid. This medicine also helps prevent bleeding in the stomach for patients with a serious illness. This medicine is a combination of a proton pump inhibitor and an antacid.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to omeprazole or sodium bicarbonate.

How to Use This Medicine

Capsule, Packet
  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Do not stop taking this medicine if your doctor told you to take it for a specific amount of time, even if you feel better.
  • Take this medicine before you eat. This medicine should be taken on an empty stomach at least 1 hour before a meal. For patients receiving continuous feeding through a tube, feeding should be temporarily stopped about 3 hours before and 1 hour after administration of Zegerid® powder for oral suspension.
  • Swallow the capsule whole with water. Do not take it with other liquids. Do not break, crush, or chew it. Do not open the capsule and sprinkle the contents into food.
  • You will need to mix the powder with water before taking it. Mix the powder with 1 to 2 tablespoons of water in a small cup. Do not use other liquids or foods. Stir well and drink right away. Refill the cup with more water and drink it.
  • To use the Zegerid® powder with a nasogastric (NG) tube or orogastric (OG) feeding tube:
    • Mix the packet of powder with approximately 20 mL of water.
    • Stir well and draw up into appropriately sized syringe.
    • Give the medicine through the nasogastric or orogastric tube into the stomach right away.
    • Refill the syringe with an equal amount of water.
    • Shake and flush any remaining contents from the nasogastric or orogastric tube into the stomach.
  • This medicine contains salt. Talk to your doctor before using this medicine if you are on a low-sodium (low-salt) diet.
  • Both 20 and 40 milligrams oral suspension packets or capsules contain the same amount of sodium bicarbonate. Do not substitute two 20 milligrams (mg) oral suspension packets or capsules with one 40 mg oral suspension packets or capsules. Talk to your doctor if you have any questions.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are also using ampicillin (Principen®, Unasyn®), atazanavir (Reyataz®), clarithromycin (Biaxin®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), ketoconazole (Nizoral®), nelfinavir (Viracept®), saquinavir (Fortovase®, Invirase®), tacrolimus (Prograf®), or voriconazole (Vfend®). Tell your doctor if you are also using diazepam (Valium®), disulfiram (Antabuse®), phenytoin (Dilantin®), an iron supplement, calcium supplements, or a blood thinner (such as warfarin, Coumadin®).
  • Tell your doctor if you take calcium supplements on a regular basis.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, if you have liver disease, kidney problems (such as Bartter's syndrome), congestive heart failure, bone problems (such as osteoporosis), or a history of hypokalemia (low potassium in the blood), or respiratory alkalosis (low levels of carbon dioxide in the blood).
  • Tell your doctor if you have Asian relatives, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of this medicine to treat erosive esophagitis.
  • This medicine is sometimes given together with other medicines to treat ulcers. Be sure you understand about the risks and proper use of any other medicine your doctor gives you together with omeprazole and sodium bicarbonate combination.
  • This medicine may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you receive high doses of this medicine or use it for one year or more.
  • Atrophic gastritis (inflammation in the stomach) may occur, especially if you take this medicine for a long time. Talk with your doctor if you have concerns about this.
  • If your symptoms do not improve or if they get worse, call your doctor.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, or red skin rash.
  • Chest pain.
  • Confusion, agitation, or depressed mood.
  • Dry mouth, increased thirst, or muscle cramps.
  • Fast, slow, or uneven heartbeat.
  • Fever.
  • Increase in how much or how often you urinate.
  • Lightheadedness, dizziness, or fainting.
  • Numbness or tingling in your hands, feet, or lips.
  • Pain on urination.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Back pain.
  • Headache.
  • Mild skin rash or itching.
  • Nausea, vomiting, constipation, diarrhea, gas, stomach pain or upset.
  • Problems with your vision or hearing.
  • Sores or white patches on your lips, mouth, or throat.
  • Weakness.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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