Dasatinib (By mouth)
Treats a cancer of the white blood cells called Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (Ph+ CML) in chronic phase (CP) and accelerated phase (AP), or myeloid or lymphoid blast phase after other treatments, such as imatinib (Gleevec®), have failed. Also used to treat newly diagnosed chronic phase Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML-CP).
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to dasatinib, or if you are pregnant or planning to become pregnant.
How to Use This Medicine
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- You may take this medicine with or without food.
- Swallow the tablet whole. Do not crush, break, or chew it.
- Keep using this medicine for as long as your doctor has told you to. Do not change your dose or stop taking this medicine without first talking with your doctor.
- Dasatinib tablets should be handled with care and people (especially pregnant personnel) who are not taking this medicine should avoid handling crushed or broken tablets. If tablets are broken or crushed, it is advisable to wear disposable chemotherapy gloves to avoid exposure to the medicine.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using medicine to treat bacterial infections (such as clarithromycin, erythromycin, telithromycin, Biaxin®, E-Mycin®, or Ketek®), medicine to treat fungus infections (such as itraconazole, ketoconazole, voriconazole, Nizoral®, or Sporanox®), medicine to treat HIV or AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Invirase®, Norvir®, Reyataz®, or Viracept®), or a blood thinner such as warfarin (Coumadin®) or aspirin.
- Tell your doctor if you also use alfentanil (Alfenta®), astemizole (Hismanal®), carbamazepine (Tegretol®), cisapride (Propulsid®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), dexamethasone (Decadron®), fentanyl (Duragesic®), nefazodone (Remeron®, Serzone®), phenobarbital (Luminal®), phenytoin (Dilantin®), pimozide (Orap®), quinidine (Cardioquin®), rifabutin (Mycobutin®), rifampicin (Rifadin®, Rimactane®), simvastatin (Zocor®), sirolimus (Rapamune®), tacrolimus (Prograf®), terfenadine (Seldane®), ergotamine medicines (such as dihydroergotamine, ergotamine, Cafergot®, D.H.E. 45®, Ergomar®, Migranal®, or Wigraine®), or St. John's wort.
- If you are using antacids (such as Maalox®, Rolaids®, or Tums®), take it at least 2 hours before or 2 hours after you take dasatinib. Tell your doctor if you also use heartburn medications such as cimetidine (Tagamet®), esomeprazole (Nexium®), famotidine (Pepcid®), lansoprazole (Prevacid®), omeprazole (Prilosec®), pantoprazole (Protonix®), rabeprazole (Aciphex®), or ranitidine (Zantac®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Use an effective form of birth control to keep from getting pregnant. Some forms of birth control include condoms, diaphragms, or birth control pills.
- Make sure your doctor knows if you are breastfeeding, or if you have a blood problem (such as anemia), bleeding problems (such as stomach bleeding), heart disease (such as congestive heart failure), heart rhythm problems (such as QT prolongation), low potassium or magnesium levels in your blood, fluid problems (edema), or problems when taking lactose.
- This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
- This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Tell your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
- Check with your doctor right away if you have the following symptoms while taking this medicine: chest discomfort or pain; decreased urine output; fast, irregular or pounding heartbeat; shortness of breath; swelling of the feet or lower legs; troubled breathing; or unusual tiredness or weakness. These could be symptoms of a serious heart problem.
- Using this medicine may cause headache, muscle or joint pain, skin rash, or unusual tiredness or weakness. If these symptoms persist and become worse, check with your doctor.
- Dasatinib may cause fluid retention. Check with your doctor right away if you have a decrease in amount of urine; noisy or rattling breathing; shortness of breath; swelling of the fingers, hands, feet, or lower legs; troubled breathing at rest; or weight gain.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Change in how much or how often you urinate.
- Chest pain.
- Fast, pounding, or uneven heartbeat.
- Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
- Lightheadedness, dizziness, drowsiness, or fainting.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Rapid weight gain.
- Red or black stools.
- Seizures or tremors.
- Severe stomach pain.
- Shortness of breath, cold sweats, and bluish-colored skin.
- Sudden or severe headache, or problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Trouble with swallowing.
- Unusual bleeding, bruising, or weakness.
- Unusually large abdomen or stomach.
- Vomiting of blood or material that looks like coffee grounds.
If you notice these less serious side effects, talk with your doctor:
- Breast enlargement (in males).
- Depression, anxiety, or confusion.
- Diarrhea, constipation, nausea, vomiting, indigestion, or stomach pain.
- Dry, irritated eyes.
- Hair loss.
- Increased sweating.
- Loss of appetite.
- Mild headache.
- Muscle or joint pain or stiffness.
- Nail changes, dry skin, or skin rash or itching.
- Ringing in the ears.
- Sores or white patches on your lips, mouth, or throat.
- Trouble with sleeping.
- Unusual taste in your mouth.
- Warmth or redness in your face, neck, arms, or upper chest.
- Weight loss.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04
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