Glimepiride (glye-MEP-ir-ide), Pioglitazone Hydrochloride (pye-oh-GLI-ta-zone hye-droe-KLOR-ide)
Used together with proper diet and exercise to help control blood sugar in adults with type 2 diabetes.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to glimepiride or pioglitazone. You should not use this medicine if you have type 1 diabetes, diabetic ketoacidosis (ketones in the blood), severe heart failure, or bladder cancer.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine with food or milk. Take this medicine with the first meal of the day.
- Carefully follow your doctor's instructions about a special diet, exercise, or weight loss. Check your blood sugar on a regular basis at home.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using other medicines to treat your diabetes, such as insulin. Tell your doctor if you are using a blood pressure medicine (such as metoprolol, propranolol, Inderal®, Lopressor®, or Tenormin®), pain or arthritis medicines (such as aspirin, Advil®, or Celebrex®), isoniazid (Nydrazid®), nicotinic acid (Nicobid®, Nicolar®), cotrimoxazole (Bactrim®, Cotrim®, Septra®), or midazolam (Versed®).
- Make sure your doctor knows if you are using chloramphenicol (Chloromycetin®, Chloroptic®), phenytoin (Dilantin®), probenecid (Benemid®), a blood thinner (such as warfarin, Coumadin®), a steroid medicine (such as methylprednisolone, prednisone, or Medrol®), or a phenothiazine medicine (such as prochlorperazine, Compazine®, Phenergan®, or Thorazine®). Tell your doctor if you are also using fluconazole (Diflucan®), gemfibrozil (Lopid®), miconazole (Lotrimin® AF, Monistat® 3), rifampin (Rifadin®, Rimactane®), hormone replacement therapy, thyroid replacement therapy, diuretics or "water pills" (such as Dyazide® or Lasix®), birth control pills, or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®).
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding. Certain women may be at an increased risk for pregnancy while taking this medicine. If you had problems ovulating and had irregular periods in the past, this medicine may cause you to ovulate. This could increase your chance of becoming pregnant. Talk to your doctor about effective birth control while you are using this medicine.
- Make sure your doctor knows if you have kidney problems, liver disease, heart disease, an adrenal or pituitary gland problem, edema (problems with fluid retention and swelling), or a history of bladder cancer. Tell your doctor if you have an eye disease such as macular edema (swelling of the back of the eye), fragile bones (especially women), or if you recently had a fever, infection, trauma, or surgery. Also, tell your doctor if you have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- This medicine may not work as well if you have surgery, get hurt, or get sick. If you have severe vomiting, diarrhea, or fever, call your doctor for instructions.
- Check with your doctor right away if you start having chest pain; shortness of breath; excessive swelling of the hands, wrist, ankles, or feet; or if you are rapidly gaining weight. These may be symptoms of a serious heart problem.
- If you have abdominal or stomach pain; dark urine; a loss of appetite; nausea or vomiting; unusual tiredness or weakness; or yellow eyes or skin, check with your doctor right away. These may be symptoms of a serious liver problem.
- This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine; a frequent, strong, or increased urge to urinate; painful urination; or pain in the back, lower abdomen, or stomach.
- Check with your doctor immediately if blurred vision, decreased vision, or any other change in vision occurs while you are taking this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
- This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments. You will also need to check your blood sugar on a regular basis at home.
- Some things that can lead to low blood sugar are exercising more than normal or waiting too long to eat. Tell your doctor about any sudden change in your medical condition.
- This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision or other changes in vision.
- Burning or painful urination, change in how much or how often you urinate.
- Dark-colored urine or pale stools.
- Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
- Lightheadedness, dizziness, shakiness, or hunger.
- Nausea, vomiting, loss of appetite, or pain in your upper stomach.
- Pain or swelling in your arms or legs without any injury.
- Rapid weight gain.
- Shortness of breath, cold sweats, and bluish-colored skin.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding or bruising.
- Unusual tiredness or weakness.
- Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, mild nausea, or vomiting.
- Muscle pain.
- Problems with your teeth.