Posaconazole (By mouth)


Prevents certain fungus infections in patients who have a weakened immune system (such as hematopoietic stem cell transplant or HSCT recipients, or patients with blood cancers). Also treats an infection in the mouth or throat called "oral thrush". This medicine is an antifungal antibiotic.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to posaconazole or to other similar medicines (such as fluconazole, itraconazole, ketoconazole, voriconazole, Diflucan®, Nizoral®, Sporanox®, or Vfend®). You should not use this medicine if you are also using ergotamine medicines (such as bromocriptine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, methysergide, Ergomar®, Ergotrate®, Methergine®, Migranal®, Parlodel®, or Sansert®), pimozide (Orap®), quinidine (Quinaglute®), simvastatin (Zocor®), or sirolimus (Rapamune®).

How to Use This Medicine

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine during or right after (within 20 minutes) a full meal or liquid nutritional supplement. It may also be taken with an acidic beverage such as ginger ale.
  • Shake the oral liquid well before using.
  • Measure the oral liquid with the marked measuring spoon that is in the package. Rinse the measuring spoon with water after using and before storage.
  • Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are using alprazolam (Xanax®), atazanavir (Reyataz®), cimetidine (Tagamet®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Digitek®, Lanoxin®), efavirenz (Sustiva®), esomeprazole (Nexium®), glipizide (Glucotrol®), metoclopramide (Reglan®), midazolam (Versed®), phenytoin (Dilantin®), rifabutin (Mycobutin®), ritonavir (Norvir®), tacrolimus (Prograf®, Protopic®), triazolam (Halcion®), vinblastine (Velban®), or vincristine (Oncovin®, Vincasar®).
  • Tell your doctor if you are also using medicines to lower cholesterol or triglycerides (such as atorvastatin, lovastatin, Lescol®, Lipitor®, or Pravachol®) or blood pressure medicines (such as diltiazem, felodipine, nicardipine, nifedipine, verapamil, Cardene®, Cartia®, Lotrel®, Norvasc®, Plendil®, or Tiazac®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a history of heart disease, heart rhythm problems (such as arrhythmia, QT prolongation), liver disease, kidney disease, or low amounts of potassium, magnesium, or calcium in your blood.
  • Tell your doctor if you have severe diarrhea or vomiting while you are using this medicine.
  • This medicine can cause serious heart rhythm problems. Tell your doctor right away if you notice a change in your heart rhythm, such as fast, pounding or uneven heartbeats.
  • Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Chest pain, shortness of breath, or coughing up blood.
  • Dark-colored urine or pale stools.
  • Dry mouth, increased thirst, or muscle cramps.
  • Fast, pounding, or uneven heartbeat.
  • Fever, chills, cough, stuffy or runny nose, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Pinpoint red or purple spots under your skin.
  • Severe diarrhea.
  • Sores or white patches on your lips, mouth, or throat.
  • Swelling in your hands, legs, ankles, or feet.
  • Tremors.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.
  • Unusual vaginal bleeding.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Back pain.
  • Constipation, mild diarrhea, stomach pain, or upset stomach.
  • Headache.
  • Joint, muscle, or bone pain.
  • Nosebleeds.
  • Skin rash or itching.
  • Trouble sleeping or anxiety.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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