Insulin glargine (Injection)


Insulin Glargine, Recombinant (IN-su-lin GLAR-jeen, ree-KOM-bi-nant)
Treats diabetes mellitus. Insulin is a hormone that helps get sugar from the blood to the muscles, where it is used for energy. This type of insulin usually works longer than regular insulin.

Brand Name(s)

There may be other brand names for this medicine.

Lantus, Lantus SoloStar

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to insulin glargine or other components of this product, or if you have diabetic ketoacidosis.

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
  • There are many different devices available for giving an insulin injection. You may be taught how to use a regular syringe or another delivery device. Each device has special instructions that you must follow. Make sure you understand all the instructions for your device before you use it.
  • Do not mix this medicine with any other insulin or with water.
  • This medicine should look clear before you use it. Do not shake the vial. If you use insulin once a day, it is best to use it at about the same time every day.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use only syringes that are specially made for insulin. It is best to always use the same brand and type of syringe and needle. Some types of insulin must be used with a certain type of syringe or needle. Ask your pharmacist if you are not sure which one to use.
  • Use a new needle and syringe each time you inject your medicine.
  • Do not change the brand or type of your insulin unless your doctor tells you to. If you must change the brand or type, ask your doctor before giving yourself an injection.
  • Carefully follow your doctor's instructions about any special diet. Your doctor may suggest that you follow an exercise program. You may also be taught to check your own blood sugar levels at home. Diet, exercise, medicine, and checking your blood sugar are all important to control your diabetes.
If a dose is missed:
  • Call your doctor or pharmacist for instructions.

How to Store and Dispose of This Medicine

  • Store unopened insulin in the refrigerator. Do not freeze. If you cannot refrigerate the insulin you will use for the day, keep it in a cool place away from heat or sunlight. Do not use insulin that has been frozen or overheated.
  • If you use an Opticlik® cartridge, keep the medicine in the refrigerator until you are ready to use it. Once you start using a cartridge, keep it at room temperature. Never store a used pen or cartridge in a refrigerator and with the needle in place. The medicine will keep for up to 28 days if protected from heat and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are using diabetes medicine that you take by mouth (such as glyburide, metformin, Actos®, Glucotrol®), ACE inhibitors (such as enalapril, lisinopril, Accupril®, Lotrel®, Zestril®), disopyramide (Norpace®), medicine to lower cholesterol or triglycerides (such as gemfibrozil, fenofibrate, Tricor®, Lopid®), fluoxetine (Prozac®), MAO inhibitors (MAOI) (such as Eldepryl®, Marplan®, Nardil®, or Parnate®), propoxyphene (Darvon®), salicylates (such as aspirin), octreotide (Sandostatin®), or medicine to treat an infection (such as trimethoprim/sulfamethoxazole, Bactrim®, Cotrim®, Septra®).
  • Tell you doctor if you are also using steroid medicines (such as dexamethasone, prednisolone, prednisone, Medrol®), danazol (Danocrine®), diuretics or "water pills" (such as hydrochlorothiazide, furosemide, torsemide, Demadex®, Lasix®), epinephrine (Adrenalin Chloride®, Sus-Phrine®), albuterol (Ventolin®, Proventil®), terbutaline (Brethine®, Bricanyl®), isoniazid (Nydrazid®, Laniazid®), phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®), somatropin (Nutropin®), thyroid hormones (such as levothyroxine, liothyronine), estrogen hormones, or birth control pills that contain progestogen.
  • Make sure your doctor knows if you are also using beta-blockers (such as atenolol, metoprolol, propranolol, Toprol®), clonidine (Catapres®), lithium (Lithane®, Lithobid®, Eskalith®), pentamidine (Pentam 300®, Nebupent®), guanethidine (Ismelin®), or reserpine (Ser-ap-es®, Hydropres®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or planning to become pregnant. Tell your doctor if you have kidney disease or liver disease.
  • You may sometimes have low blood sugar while you are using insulin. This is more likely if you miss a meal, exercise for a long time, or drink alcohol. If your blood sugar gets too low, you may feel weak, drowsy, confused, anxious, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, or a headache that will not go away. If you have symptoms of low blood sugar (hypoglycemia), check your blood sugar. If your blood sugar is 70 mg/dL (milligrams per deciliter) or below, do one of the following: Drink 4 ounces (one-half cup) of fruit juice, or eat 5 to 6 pieces of hard candy, or take 2 to 3 glucose tablets. Recheck your blood sugar 15 minutes later. If your blood sugar goes above 70 mg/dL, eat a snack or a meal. If your blood sugar is still below 70 mg/dL, drink one-half cup juice, or eat 5 to 6 pieces of candy, or take 2 to 3 glucose tablets. Carry candy or some type of sugar with you at all times, especially if you are away from home. You can take this if you feel that your blood sugar is too low, even if you do not have a blood glucose meter. Always carefully follow your doctor's instructions about how to treat your low blood sugar. Learn what to do if your blood sugar gets too low. Teach friends, coworkers, and family members what they can do to help if you have low blood sugar.
  • Never share insulin pens or cartridges with others under any circumstances. It is not safe for one pen to be used for more than one person. Sharing needles or pens can result in transmission of hepatitis viruses, HIV, or other blood-borne illnesses.
  • Your correct insulin dose may change slightly with changes in your diet or activity. Your dose needs may also change if you are ill (especially with vomiting or diarrhea), stressed out, pregnant, traveling, using a new medicine, or exercising more or less than usual. Follow your doctor's instructions about changes in your insulin dose.
  • This medicine should not be used if you have symptoms of very high blood sugar. These may include blurred vision; fruit-like breath odor; increased hunger, thirst, or urination; trouble breathing; fast heartbeat; or confusion or other mental changes. If you have any of these symptoms, check with your doctor right away. You may need a different medicine to treat your condition.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Anxiety, confusion, restlessness, or mood or mental changes.
  • Blurred vision, or any changes in vision.
  • Fast, pounding, or irregular heartbeat.
  • Headache, lightheadedness, dizziness, or drowsiness.
  • Increased sweating.
  • Problems with walking.
  • Slurred speech.
  • Tingling in your hands, feet, lips, or tongue.
  • Tremors.
  • Trouble breathing.
If you notice these less serious side effects, talk with your doctor:
  • Nightmares or trouble sleeping.
  • Redness, pain, itching, burning, swelling, or a lump under your skin where the shot is given.
  • Skin itching or rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
Adam Data Copyright The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only--they do not constitute endorsements of those other sites. © 1997- 2010 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

For information 410.787.4000

© 2015 UM Baltimore Washington Medical Center.  All rights reserved.

301 Hospital Drive, Glen Burnie, MD 21061 | 410-787-4000 | TTY 410-787-4498