Aliskiren (By mouth)

Introduction

Aliskiren (a-lis-KYE-ren)

Used alone or with other medicines to treat high blood pressure. This medicine is a renin inhibitor.

Brand Name(s)

There may be other brand names for this medicine.

Tekturna

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to aliskiren, or if you are pregnant.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take this medicine with or without food.
  • Carefully follow your doctor's instructions about any special diet.
  • Take this medicine at the same time each day.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using atorvastatin (Lipitor®), furosemide (Lasix®), ketoconazole (Nizoral®), or any other medicine for a heart problem or high blood pressure (such as irbesartan, Avapro®). Tell your doctor if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), certain diuretics or "water pills" (such as spironolactone, triamterene, or Aldactone®), or medicines or supplements containing potassium.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant (especially in your second or third trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, history of airway surgery, or a mineral imbalance (such as high amounts of potassium in the blood).
  • This medicine can cause a serious reaction called angioedema. Stop using this medicine and tell your doctor right away if you start to have swelling of your face, lips, tongue, throat, arms, or legs, or if you are having trouble swallowing or breathing.
  • This medicine may make you dizzy or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are dizzy. If you feel dizzy, lie or sit down so you do not faint. The dizziness may be worse if you lose too much water from your body. You can lose water by sweating or by having diarrhea and vomiting. Tell your doctor if this medicine makes you feel lightheaded or dizzy after you have had diarrhea or vomiting.
  • If you stop using this medicine, your blood pressure may go up. High blood pressure will not make you feel sick. Even if you feel well, do not stop using this medicine without talking to your doctor.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blood in the urine, lower back pain, side pain, or sharp back pain just below the ribs.
  • Confusion, weakness, uneven heartbeat, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Convulsions (seizures).
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, stomach pain, upset stomach, or heartburn.
  • Joint pain or stiffness.
  • Skin rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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