Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide), Sitagliptin Phosphate (sit-a-GLIP-tin FOS-fate)
Treats type 2 diabetes. Used together with proper diet and exercise to help control high blood sugar.
There may be other brand names for this medicine.
Janumet, Janumet XR
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to metformin or sitagliptin, or if you have kidney disease, or metabolic acidosis (including diabetic ketoacidosis).
How to Use This Medicine
Tablet, Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine with food or milk.
- Extended-release tablet: Take as directed in the evening.
- Swallow the tablet whole. Do not crush, break, or chew it.
- Carefully follow your doctor's instructions about any special diet or exercise program. Test your blood sugar regularly.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use insulin or other diabetes medicine that you take by mouth, such as glimepiride, glipizide, glyburide, tolbutamide, Actos®, Amaryl®, Avandia®, Glucotrol®, or Orinase®.
- Make sure your doctor knows if you are also using acetazolamide (Diamox®), cimetidine (Tagamet®), dichlorphenamide (Daranide®), digoxin (Digitek®, Lanoxin®), isoniazid (Nydrazid®), morphine, niacin (vitamin B3), phenytoin (Dilantin®), procainamide (Procanbid®), quinidine (Quinidex®), quinine (Qualaquin®), ranitidine (Zantac®), topiramate (Topamax®), trimethoprim (Proloprim®, Trimpex®), vancomycin (Vancocin®), or zonisamide (Zonegram®).
- Tell your doctor if you are also using certain blood pressure medicines (such as amlodipine, atenolol, diltiazem, metoprolol, nifedipine, verapamil, Caduet®, Cardizem®, Lotrel®, Procardia®), a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, triamterene, Dyrenium®, Lasix®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), or a thyroid replacement (such as levothyroxine, liothyronine, Cytomel®, Synthroid®), estrogen hormones (such as Premarin®), or birth control pills.
- Do not drink excessive amounts of alcohol while taking this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney problems, liver disease, congestive heart failure, heart disease, adrenal or pituitary problems, anemia, or vitamin B12 deficiency. Make sure your doctor knows if you are injured or sick, especially if you are dehydrated, or you have an infection, severe vomiting, diarrhea, or fever.
- Do not use this medicine to treat type 1 diabetes.
- Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you have sudden and severe stomach pain, nausea, vomiting, fever, or lightheadedness. Tell your doctor if you drink alcohol or have gallstones, high cholesterol, or high triglycerides, or if you have had pancreas problems before. These conditions may increase your risk for pancreatitis.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an X-ray or CT scan.
- Rarely, this medicine may cause a serious condition called lactic acidosis. Call your doctor right away if you feel sick and drowsy, have muscle pain, trouble breathing, upset stomach, and slow heartbeat. Lactic acidosis is more likely to happen if you have kidney or liver problems, a severe infection (sepsis), severe heart failure, are severely dehydrated, or drink large amounts of alcohol.
- Rarely, this medicine may cause kidney problems, sometimes requiring dialysis.
- You could develop low blood sugar while you are taking this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Tell your doctor if this happens. Low blood sugar may be caused by exercising more than normal or waiting too long to eat.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.You will also need to check your blood sugar regularly at home.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Bluish lips or skin
- Change in how much or how often you urinate
- Extreme weakness, tiredness, or confusion
- Fast heartbeat, cold sweat
- Increased hunger
- Lightheadedness, dizziness, or fainting
- Rapid or troubled breathing, nausea and vomiting
- Shaking, trembling
- Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness
If you notice these less serious side effects, talk with your doctor:
- Cough, runny or stuffy nose, or sore throat
- Diarrhea, mild stomach pain, or upset stomach