Maraviroc (By mouth)

Introduction

Maraviroc (mar-a-VIR-ok)

Treats human immunodeficiency virus (HIV) infection. HIV causes acquired immune deficiency syndrome (AIDS). This medicine does not cure HIV or AIDS, but combinations of drugs that treat HIV infection may slow the progress of the disease. This medicine is usually given to patients who have received HIV treatment in the past.

Brand Name(s)

There may be other brand names for this medicine.

Selzentry

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to maraviroc, or if you are taking certain other medicines and have severe kidney disease that may require dialysis.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.
  • Maraviroc is used with other medicines to treat HIV infection. Make sure you take all of the medicines your doctor ordered. Do not stop taking this medicine, even for a short time, unless your doctor tells you to.
  • This medicine works best if there is a constant amount in the blood. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses. Also, when your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of this medicine.
  • You may take this medicine with or without food.
  • Swallow the tablet whole. Do not crush, break, or chew it.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If your next regular dose is less than 6 hours away, wait until then to use the medicine and skip the missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using St. John's wort, clarithromycin (Biaxin®), itraconazole (Sporanox®), ketoconazole (Nizoral®), nefazodone (Serzone®), rifampin (Rifadin®, Rimactane®), telithromycin (Ketek®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Carbatrol®, Dilantin®, or Tegretol®), or other medicines to treat HIV or AIDS (such as atazanavir, darunavir, delavirdine, efavirenz, etravirine, fosamprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Intelence®, Invirase®, Kaletra®, Norvir®, Lexiva®, Prezista®, Rescriptor®, Reyataz®, Sustiva®, or Viracept®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant, or if you have heart disease, liver disease (including hepatitis B or C), kidney disease, or low blood pressure.
  • You should not breast feed if you have HIV or AIDS, because you may give the infection to your baby through your breast milk.
  • When you start taking HIV medicines, your immune system may get stronger. If you have infections that are hidden in your body, such as pneumonia, herpes, or tuberculosis, you may notice new symptoms when your body tries to fight them. If this occurs, be sure to tell your doctor right away.
  • Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.
  • This medicine will not keep you from giving HIV to your partner during sex. Make sure you understand and practice safe sex, even if your partner also has HIV. Do not share needles with anyone.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate, or painful urination.
  • Chest pain.
  • Dark-colored urine or pale stools.
  • Dizziness, lightheadedness, or faintness when getting up suddenly from a lying or sitting position.
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Painful cold sores or blisters on lips, nose, eyes, or genitals.
  • Shortness of breath or rapid breathing.
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Unusual bleeding, bruising, or weakness.
  • Unusual rash or lumps on the skin.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Changes in appetite.
  • Constipation, diarrhea, or stomach pain or upset.
  • Depression, confusion, or trouble sleeping.
  • Joint or muscle pain.
  • Mild skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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