Doripenem (Injection)


Doripenem (dor-i-PEN-em)
Treats infections caused by bacteria. This medicine is an antibiotic.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to doripenem or similar medicines, such as ertapenem (Invanz®), imipenem/cilastatin (Primaxin®), or meropenem (Merrem®). You should not receive this medicine if you have also had an allergic reaction to other antibiotics, such as amoxicillin (Amoxil®), ampicillin (Principen®), cefaclor (Ceclor®), cefotaxime (Claforan®), ceftriaxone (Rocephin®), cephalexin (Keflex®), penicillin, piperacillin (Pipracil®), or ticarcillin (Ticar®).

How to Use This Medicine

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are using probenecid (Benemid®) or valproic acid (Depakene®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease or a history of seizures.
  • If you have severe diarrhea, ask your doctor before taking any medicine to stop the diarrhea.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble breathing; or chest pain after you receive the injection.
  • Do not use this medicine for any condition that has not been checked by a doctor. This antibiotic will not treat the flu or common cold.
  • If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate.
  • Difficulty with breathing or shortness of breath.
  • Fever, chills, cough, sore throat, and body aches.
  • Pain, tenderness, or swelling of the foot or leg.
  • Seizures.
  • Severe diarrhea (watery or bloody).
  • Sores or white patches on your mouth or tongue.
  • Unusual bleeding, bruising, or weakness.
  • Vaginal discharge, itching, or pain.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Blistering, peeling, or loosening of skin.
  • Headache.
  • Mild diarrhea or nausea.
  • Pain, redness, tenderness, or swelling on your skin where the needle is placed.
  • Skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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