Aliskiren (a-lis-KYE-ren), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide)
Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine is a combination of a renin inhibitor and a thiazide diuretic (water pill).
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to aliskiren, hydrochlorothiazide, or a sulfonamide (sulfa drug), or if you are pregnant. Do not use this medicine if you are not able to urinate. Do not use this medicine if you have diabetes and are also taking another blood pressure medicine called an ACE inhibitor (angiotensin-converting enzyme inhibitor) or an ARB (angiotensin receptor blocker).
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Take this medicine the same way every day. Take it at the same time every day and take it consistently with or without food. Avoid taking this medicine with a high-fat meal.
- Carefully follow your doctor's instructions about any special diet.Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the tablets in its original container in a dry place.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- You should not use this medicine if you also use cyclosporine (Gengraf®, Neoral®, Sandimmune®) or itraconazole (Sporanox®), unless your doctor specifically says that it is okay.
- Make sure your doctor knows if you are using atropine, biperiden (Akineton®), cholestyramine (Locholest®, Prevalite®, Questran®), colestipol (Colestid®), lithium (Eskalith®, Lithobid®), cyclophosphamide (Cytoxan®), or methotrexate (Rheumatrex®). Tell your doctor if you are also using another blood pressure medicine (such as benazepril, enalapril, lisinopril, Avalide®, Avapro®, Benicar®, Cozaar®, Diovan®, Lotrel®, Micardis®, Vasotec®, Zestril®, Zestoretic®), a diuretic (water pill, such as amiloride, spironolactone, triamterene, Aldactone®), insulin or an oral diabetes medicine (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®).
- Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
- Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.
Warnings While Using This Medicine
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding or if you have kidney problems, liver disease, heart or blood vessel disease (including heart failure or a history of a heart attack), diabetes, glaucoma, gout, high cholesterol levels, low blood pressure, or lupus. Tell your doctor if you have a mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood) or a history of asthma or allergies. Tell your doctor if you have had surgery on your throat or other parts of your respiratory system.
- This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
- Check with your doctor immediately if you have blurred vision, trouble seeing, eye pain, or any other change in vision.
- Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Change in how much or how often you urinate
- Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
- Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
- Joint pain
- Lightheadedness, dizziness, fainting
- Trouble seeing, eye pain
- Rapid weight gain, swelling in your hands, ankles, or feet
If you notice these less serious side effects, talk with your doctor: