Sumatriptan/naproxen (By mouth)


Naproxen (na-PROX-en), Sumatriptan (soo-ma-TRIP-tan)
Treats migraine headaches.

Brand Name(s)

There may be other brand names for this medicine.


When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to sumatriptan, naproxen, aspirin, or other NSAID medicines (such as diclofenac, ibuprofen, Advil®, Celebrex®, or Ecotrin®). Do not use this medicine if you have a history of heart disease, heart attack, angina (chest pain), stroke, transient ischemic attack (TIA), ischemic bowel disease, peripheral vascular disease, liver disease, or right before or after having a heart bypass surgery. You should not use this medicine to prevent migraine headache attacks, or if you have uncontrolled high blood pressure, or migraine headaches of the hemiplegic or basilar type. Do not use this medicine if you have used an MAO inhibitor (MAOI) such as isocarboxacid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®), or tranylcypromine (Parnate®) within the past two weeks. Do not use this medicine if you have taken other migraine medicines such as almotriptan (Axert?), frovatriptan (Frova®), naratriptan (Amerge®), rizatriptan (Maxalt®), or zolmitriptan (Zomig®) in the past 24 hours. Do not use this medicine if you have used an ergotamine medicine (such as methysergide, Cafergot®, D.H.E. 45®, Ergomar®, or Migranal®) within the past 24 hours.

How to Use This Medicine

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • If your headache comes back or does not go away after taking this medicine, wait at least two hours before taking another dose. Do not take more than two doses in 24 hours.
  • You may take this medicine with or without food.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • Use this medicine for the shortest time possible and in the smallest dose possible. This will help lower the risk of side effects.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
  • Make sure your doctor knows if you are using aspirin, methotrexate (Rheumatrex®), lithium (Eskalith®), probenecid (Benemid®), warfarin (Coumadin®), certain blood pressure medicines (such as captopril, enalapril, lisinopril, Accupril®, Altace®, or Lotrel®), beta-blocker medicine (such as propranolol), or a diuretic (water pill) such as furosemide or Lasix®.
  • Tell your doctor if you are also using medicine to treat depression (such as citalopram, duloxetine, escitalopram, paroxetine, fluoxetine, olanzapine, sertraline, fluvoxamine, venlafaxine, Celexa®, Lexapro®, Cymbalta®, Effexor®, Paxil®, Prozac®, or Zoloft®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding. You should not use this medicine during the later part of pregnancy unless your doctor tells you to.
  • Tell your doctor if you have heart disease (such as congestive heart failure), edema (swelling), high blood pressure, high cholesterol, kidney disease, liver problems, diabetes, epilepsy, bleeding problems, anemia, or asthma. Tell your doctor if you are obese, over 40 years of age, or have gone through menopause.
  • This medicine may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
  • This medicine might cause bleeding or ulcers in your stomach or intestines. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner).
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, red skin rash.
  • Bloody or black, tarry stools.
  • Change in how much or how often you urinate.
  • Chest pain or discomfort, shortness of breath, cold sweat, coughing up blood, or bluish-colored skin.
  • Fast, pounding, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Pain in your lower leg (calf).
  • Problems with vision, speech, or walking.
  • Severe stomach pain.
  • Sudden or severe headache.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Unusual weight gain.
  • Vomiting blood or something that looks like coffee grounds.
  • Yellowing of your skin or the whites of your eyes.
If you notice these less serious side effects, talk with your doctor:
  • Dizziness or drowsiness.
  • Mild skin rash or itching.
  • Nausea, upset stomach, or dry mouth.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Review Date: 2011-02-04 Reviewed By: Keywords: ,
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