Repaglinide/metformin (By mouth)

Introduction

Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide), Repaglinide (re-PAG-li-nide)

Treats type 2 diabetes. Used together with proper diet and exercise to help control blood sugar levels.

Brand Name(s)

There may be other brand names for this medicine.

PrandiMet

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to repaglinide or metformin, or if you have kidney disease, type 1 diabetes, or metabolic acidosis (including diabetic ketoacidosis). Do not use this medicine if you are also using gemfibrozil (Lopid®) and itraconazole (Sporanox®).

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with food or milk.
  • Carefully follow your doctor's instructions about any special diet or exercise program.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using amiloride (Midamor®), digoxin (Lanoxin®), ketoconazole (Nizoral®), morphine (Duramorph®), procainamide (Procanbid®), quinidine (Quinora®), quinine, ranitidine (Zantac®), rifampin (Rifadin®), triamterene (Dyrenium®), trimethoprim (Trimpex®), or vancomycin (Vancocin®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, kidney problems, liver disease, problems with your adrenal or pituitary gland, or if you use insulin to treat your diabetes. Tell your doctor if you get an infection while you are using this medicine.
  • This medicine may cause a rare, but serious condition called lactic acidosis in some people. Call your doctor right away if you get sick, or if you have unusual tiredness, weakness, muscle pain, stomach pain, trouble breathing, fever, or nausea.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.This medicine may interact with the dye used for an X-ray or CT scan.
  • If your blood sugar gets too low, you may feel weak, drowsy, confused, anxious, or very hungry. You may also sweat, shake, or have blurred vision, a fast heartbeat, or a headache that will not go away. If you have symptoms of low blood sugar (hypoglycemia), check your blood sugar. If your blood sugar is 70 mg/dL (milligrams per deciliter) or below, do one of the following: Drink 4 ounces (one-half cup) of fruit juice, or eat 5 to 6 pieces of hard candy, or take 2 to 3 glucose tablets. Recheck your blood sugar 15 minutes later. If your blood sugar goes above 70 mg/dL, eat a snack or a meal. If your blood sugar is still below 70 mg/dL, drink one-half cup juice, or eat 5 to 6 pieces of candy, or take 2 to 3 glucose tablets. Carry candy or some type of sugar with you at all times, especially if you are away from home. You can take this if you feel that your blood sugar is too low, even if you do not have a blood glucose meter. Always carefully follow your doctor's instructions about how to treat your low blood sugar. Learn what to do if your blood sugar gets too low. Teach friends, coworkers, and family members what they can do to help if you have low blood sugar.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Blistering, peeling, or red skin rash.
  • Chest pain.
  • Dizziness, shakiness, or increased thirst.
  • Extreme weakness, tiredness, or confusion.
  • Fast, pounding, or irregular heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness or fainting.
  • Sudden and severe stomach pain, nausea, or vomiting.
  • Unusual bleeding or bruising.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea.
  • Headache.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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