Pazopanib (By mouth)

Introduction

Pazopanib (paz-OH-pa-nib)

Treats late-stage kidney cancer.

Brand Name(s)

There may be other brand names for this medicine.

Votrient

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to pazopanib, or if you are pregnant.

How to Use This Medicine

Tablet

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine on an empty stomach. Take this medicine at least one hour before or 2 hours after a meal.
  • Swallow the tablets whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
  • If you miss a dose or forget to use it, and it is less than 12 hours since your last dose, wait and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using clarithromycin (Biaxin®), ketoconazole (Nizoral®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), or medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, procainamide, propafenone, quinidine, sotalol, Cardioquin®, Cordarone®, Norpace®, Procanbid®, Rythmol®, Tambocor®, or Tikosyn®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, high blood pressure, heart rhythm problems (such as QT prolongation), thyroid problems, or a history of severe chest pain, heart attack, or stroke. Tell your doctor if you have coughed up blood for the last 6 months, stomach or bowel problems (such as bleeding for the last 6 months), or had a recent surgery.
  • Liver problems may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.
  • This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
  • You will also need to have your blood pressure measured before starting this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away. If you have questions about this, talk to your doctor.
  • This medicine may increase your chance of bleeding. To help with this problem, stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Check with your doctor right away if you start having severe abdominal or stomach burning, cramps, or pains; bloody or black, tarry stools; trouble breathing; heartburn; indigestion; nausea; or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Black, tarry stools.
  • Chest pain.
  • Cloudy urine.
  • Dark-colored urine or pale stools.
  • Fast, pounding, or uneven heartbeat.
  • Lightheadedness, dizziness, or fainting.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Numbness or weakness on one side of your body.
  • Pain in your arms, back, neck, or jaw.
  • Pain or swelling in your stomach.
  • Redness, pain, swelling, or blisters on the palms of your hands or the soles of your feet.
  • Unusual bleeding, bruising, or weakness.
  • Vomiting of blood or material that looks like coffee grounds.
  • Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

  • Change in hair color.
  • Change or bad taste in your mouth.
  • Diarrhea.
  • Hair loss.
  • Headache.
  • Rash.
  • Weight loss.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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