Dalfampridine (By mouth)

Introduction

Dalfampridine (dal-FAM-pri-deen)

Helps improve walking in patients with multiple sclerosis. This medicine is a potassium channel blocker.

Brand Name(s)

There may be other brand names for this medicine.

Ampyra

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to dalfampridine, or if you have a history of seizures, or have moderate or severe kidney disease.

How to Use This Medicine

Long Acting Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take this medicine with or without food.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.Do not take more than two tablets in a 24-hour period.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, bladder problems, or seizures.
  • Do not take dalfampridine together with other aminopyridine medicines (e.g., compounded 4-AP, fampridine). Taking these medicines together will increase the chance for more serious side effects.
  • Urinary tract infections may occur while using this medicine. Check with your doctor right away if you have the following symptoms while using this medicine: bladder pain; bloody or cloudy urine; difficult, burning, or painful urination; frequent urge to urinate; or lower back or side pain.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Change in how much or how often you urinate, or painful urination.
  • Numbness or tingling in your arms, legs, or face.
  • Problems with balance or walking.
  • Seizures.
  • Slurred speech or problems with swallowing.

If you notice these less serious side effects, talk with your doctor:

  • Back pain or headache.
  • Constipation, nausea, heartburn, or upset stomach.
  • Dizziness.
  • Stuffy or runny nose, sore throat.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: 2011-02-04 Reviewed By: Keywords: ,
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