If you are currently being treated with any of the following medications, you should not use 5-HTP without first talking to your healthcare provider.
Antidepressants -- People who are taking antidepressant medications should not take 5-HTP. These medications could combine with 5-HTP to cause serotonin syndrome, a dangerous condition characterized by mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma. Antidepressant medications that can interact with 5-HTP include:
- SSRIs: Citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), fluoxetine (Prozac), sertraline (Zoloft)
- Tricyclics: Amitriptyline (Elavil), nortryptyline (Pamelor), imipramine (Tofranil)
- Monoamine oxidase inhibitors (MAOIs): Phenelzine, (Nardil), tranylcypromine (Parnate)
- Nefazodone (Serzone)
Carbidopa -- Taking 5-HTP with carbidopa, a medication used to treat Parkinson's disease, may cause a scleroderma-like illness (a condition in which the skin becomes hard, thick, and inflamed).
Tramadol (Ultram) -- Tramadol, used for pain control and sometimes prescribed for people with fibromyalgia, may also increase serotonin levels too much if taken in combination with 5-HTP. Serotonin syndrome has been reported in some people taking the two together.
Triptans (used to treat migraines) -- 5-HTP can increase the risk of side effects, including serotonin syndrome, when taken with these medications:
- Naratriptan (Amerge)
- Rizatriptan (Maxalt)
- Sumatriptan (Imitrex)
- Zolmitriptan (Zomig)
Antidepressant MedicationsCarbidopaMAO InhibitorsSelective Serotonin Reuptake Inhibitors (SSRIs)TramadolVenlafaxine
5-HTP; 5-Hydroxytryptophan (5-HTP)